Valproate-Induced Metabolic Syndrome
Shnayder N.A. Grechkina V.V. Trefilova V.V. Efremov I.S. Dontceva E.A. Narodova E.A. Petrova M.M. Soloveva I.A. Tepnadze L.E. Reznichenko P.A. Al-Zamil M. Altynbekova G.I. Strelnik A.I. Nasyrova R.F.
May 2023MDPI
Biomedicines
2023#11Issue 5
Valproic acid (VPA) and its salts (sodium calcium magnesium and orotic) are psychotropic drugs that are widely used in neurology and psychiatry. The long-term use of VPA increases the risk of developing adverse drug reactions (ADRs), among which metabolic syndrome (MetS) plays a special role. MetS belongs to a cluster of metabolic conditions such as abdominal obesity, high blood pressure, high blood glucose, high serum triglycerides, and low serum high-density lipoprotein. Valproate-induced MetS (VPA-MetS) is a common ADR that needs an updated multidisciplinary approach to its prevention and diagnosis. In this review, we consider the results of studies of blood (serum and plasma) and the urinary biomarkers of VPA-MetS. These metabolic biomarkers may provide the key to the development of a new multidisciplinary personalized strategy for the prevention and diagnosis of VPA-MetS in patients with neurological diseases, psychiatric disorders, and addiction diseases.
metabolic syndrome , metabolome , metabolomic , personalized approach , valproic acid
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Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, Saint Petersburg, 192019, Russian Federation
Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russian Federation
Department of Neurology, Hospital for War Veterans, Saint Petersburg, 193079, Russian Federation
Department of Psychiatry and Narcology, Bashkir State Medical University, Ufa, 450008, Russian Federation
Federal Centre for Neurosurgery, Novosibirsk, 630087, Russian Federation
Department of Physiotherapy, Faculty of Continuing Medical Education, Peoples’ Friendship, University of Russia, Moscow, 117198, Russian Federation
Department of Psychiatry and Narcology, S.D. Asfendiarov Kazakh National Medical University, Almaty, 050022, Kazakhstan
International Centre for Education and Research in Neuropsychiatry, Samara State Medical University, Samara, 443016, Russian Federation
Institute of Personalized Psychiatry and Neurology
Shared Core Facilities “Molecular and Cell Technologies”
Department of Neurology
Department of Psychiatry and Narcology
Federal Centre for Neurosurgery
Department of Physiotherapy
Department of Psychiatry and Narcology
International Centre for Education and Research in Neuropsychiatry
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