Phytochemistry, Pharmacological Potential, and Ethnomedicinal Relevance of Achillea nobilis and Its Subspecies: A Comprehensive Review
Shevchenko A. Аkhelova A. Nokerbek S. Kaldybayeva A. Sagyndykova L. Raganina K. Dossymbekova R. Meldebekova A. Amirkhanova A. Ikhsanov Y. Sauranbayeva G. Kamalova M. Toregeldieva A.
June 2025Multidisciplinary Digital Publishing Institute (MDPI)
Molecules
2025#30Issue 11
Achillea nobilis and its subspecies (A. nobilis subsp. neilreichii and A. nobilis subsp. sipylea) have been traditionally used in various ethnomedical systems across Eurasia. However, comprehensive studies on their phytochemical composition and pharmacological properties are still insufficient. This review aims to provide a critical synthesis of current knowledge regarding the botanical characteristics, geographic distribution, traditional applications, chemical constituents, and pharmacological effects of A. nobilis A structured search was conducted using eight scientific platforms, including Scopus, PubMed, Web of Science, Google Scholar, Science.gov, ScienceDirect, JSTOR, and BASE. Keywords related to phytochemistry, pharmacology, and ethnomedicine were applied, and a total of 28,000 records were initially retrieved. After a multi-stage screening process based on inclusion and exclusion criteria, 167 peer-reviewed publications from 1952 to 2023 were selected for detailed evaluation. Findings reveal a diverse range of bioactive compounds, such as flavonoids, monoterpenes, sesquiterpenes, and sesquiterpene lactones, which demonstrate antioxidant, antimicrobial, anti-inflammatory, antinociceptive, antispasmodic, and anticonvulsant activities. Most studies have focused on aerial parts and water-based extracts, while the root chemistry and organ-specific metabolite profiles remain largely unexplored. This review highlights the therapeutic potential of A. nobilis and underscores the need for future studies using multi-omics and advanced analytical techniques to support its development in pharmaceutical and nutraceutical applications.
antibacterial , antinociceptive , ethnomedicine , flavonoids , monoterpenes , pharmacological activities , phytochemistry
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Higher School of Medicine, Al-Farabi Kazakh National University, Tole-bi 96, Almaty, 050040, Kazakhstan
Department of Chemistry and Technology of Organic Substances, Natural Compounds and Polymers, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Pharmaceutical and Toxicological Chemistry, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty, 050012, Kazakhstan
School of Pharmacy, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty, 050012, Kazakhstan
Department of Pharmaceutical Disciplines, Astana Medical University, Saryarqa Ave., 33, Astana, 010000, Kazakhstan
Department of Pharmaceutical Technology, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty, 050012, Kazakhstan
Department of Biochemistry, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty, 050012, Kazakhstan
Department of Biotechnology, Faculty of Biology and biotechnology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Biotechnology and General Chemical Engineering, School of Pharmacy, S.D. Asfendiyarov Kazakh National Medical University, Tole-bi 94, Almaty, 050012, Kazakhstan
Higher School of Medicine
Department of Chemistry and Technology of Organic Substances
Department of Pharmaceutical and Toxicological Chemistry
School of Pharmacy
Department of Pharmaceutical Disciplines
Department of Pharmaceutical Technology
Department of Biochemistry
Department of Biotechnology
Department of Biotechnology and General Chemical Engineering
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