Soluble and Cellular Inflammatory Predictive Markers Associated with Recurrent Pregnancy Loss Among Kazakhstani Women: a Pilot Study
Shertay D. Aimagambetova G. Tursunov A. Ukybassova T. Marat A. Sharipova M. Almawi W.Y. Atageldiyeva K.
2024National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2024#21Issue 515 - 20 pp.
Background: Recurrent pregnancy loss (RPL) is a common complication of pregnancy globally, characterized by multiple miscarriages but with poorly explained etiologies. Insofar as a state of low-grade inflammation (LGI) accompanies RPL, this study explores the link between RPL and markers of LGI among Kazakhstani women. Methods: The retrospective study was conducted on 112 Kazakh women, comprising 64 with a confirmed diagnosis of RPL and 48 women with two or more uncomplicated pregnancies serving as controls. Statistical analysis was performed on SPSS 29 software. Results: All tested blood analytes, including CRP, glucose, cholesterol, LDL-cholesterol, Hemoglobin, and RBC counts, were negatively associated with RPL. The only exception was neutrophil values having a positive association with RPL despite a lack of significant correlation between groups. Conclusion: The study shows a marginal association between the LGI biomarkers considered and the overall risk factors of RPL in Kazakh women, which is in apparent contradiction with earlier studies. The absence of parallel studies in Central Asian countries hampers the analysis of study trends in related communities. Future case-control studies with more sample sizes are needed to explore the RPL biomarkers in depth.
Kazakhstan , low grade inflammation , recurrent miscarriages , recurrent pregnancy loss , RPL markers
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School of Medicine, Nazarbayev University, Astana, Kazakhstan
Department of Surgery, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Clinical Academic Department of Womens Health, CF “University Medical Center”, Astana, Kazakhstan
Department of Obstetrics and Gynecology #1, NJSC “Astana Medical University”, Astana, Kazakhstan
Science Faculty of Tunisia, Université de Tunis El Manar, Tunis, Tunisia
Department of Biological Sciences, Brock University, St.Catharines, ON, Canada
Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan
School of Medicine
Department of Surgery
Clinical Academic Department of Womens Health
Department of Obstetrics and Gynecology #1
Science Faculty of Tunisia
Department of Biological Sciences
Department of Medicine
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