Effects of Glucagon-like Peptide-1 Receptor Agonists on Cardiac Function, Exercise Capacity and Quality of Life
Shchendrygina A. Rakisheva A. Giverts I. Rustamova Y. Soloveva A.
2024Radcliffe Medical Media
Cardiac Failure Review
2024#10
Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are emerging glucose-lowering agents primarily used in managing diabetes and obesity. Recently, GLP-1 RAs have garnered attention for their cardiovascular benefits beyond glycaemic control in patients with type 2 diabetes, exhibiting patterns previously seen in cardiovascular outcomes trials on sodium–glucose cotransporter 2 inhibitors, which now receive a high level of recommendation for the treatment of heart failure (HF). GLP-1 RAs have been increasingly investigated in HF cohorts, but mainly in small-scale studies reporting inconclusive findings regarding clinical outcomes and different safety profiles in HF patients with reduced and preserved ejection fractions. This review discusses the effects of GLP-1 RAs on surrogate HF outcomes, such as cardiac structure and function, exercise capacity and quality of life, in HF patients across the spectrum of left ventricular ejection fraction, to provide insights into the potential of these agents to be investigated in large clinical trials to evaluate clinical outcomes.
cardiac function , exercise capacity , Glucagon-like peptide-1 receptor agonists , heart failure , quality of life
Text of the article Перейти на текст статьи
Department of Hospital Therapy No. 2, IM Sechenov First Moscow State Medical University, Moscow, Russian Federation
Department of Cardiology, City Cardiology Center, Almaty, Kazakhstan
Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY, United States
The Cardiovascular Research Center, Massachusetts General Center, Boston, MA, United States
Department of Internal Medicine, Educational-Surgery Clinic, Azerbaijan Medical University, Baku, Azerbaijan
Department of Cardiology, Almazov National Medical Research Centre, Saint Petersburg, Russian Federation
Department of Hospital Therapy No. 2
Department of Cardiology
Department of Internal Medicine
The Cardiovascular Research Center
Department of Internal Medicine
Department of Cardiology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026