Unveiling the Therapeutic Potential of Modern Probiotics in Addressing Neurodegenerative Disorders: A Comprehensive Exploration, Review and Future Perspectives on Intervention Strategies
Sharma H. Pathak R. Biswas D.
2025Bentham Science Publishers
Current Psychiatry Research and Reviews
2025#21Issue 4489 - 513 pp.
The continual deterioration of the structure and function of the nervous system is a major global health problem associated with neurodegenerative disorders. Gut-brain axis plays a significant role in linking gut microbiota to neurological function. Live micro organisms that benefit the host’s health are called probiotics. These probiotics are increas ingly recognized as beneficial for treating neurodegenerative diseases. This review investi gates the impact of probiotics on neurodegenerative disorders, specifically focusing on conditions like Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis. According to studies, probiotics have the power to alter the host’s neuroimmune response, lower in flammation, and modify the composition of the gut microbiota. Studies have indicated a potential relationship between the stomach and the brain by connecting variations in the gut microbiota to neurodegenerative diseases. Probiotics can influence the gut flora, which leads to a reduction in neuroinflammation, oxidative stress, and other pathological pro cesses linked with these conditions. This review also discusses how probiotics impact the central nervous system through mechanisms such as altered blood-brain barrier function, neurotrophic factor regulation, and neurotransmitter production. Based on preclinical and clinical data, probiotics are also highlighted as an adjunctive or prophylactic treatment for neurodegenerative diseases. More research is needed to find the exact strains, dosages, and duration of probiotic therapies required to have the greatest neuroprotective effects, despite the good results thus far. It is also acknowledged that translating findings from animal studies to human applications can be challenging. With the ability to reduce the neuropa thological features of Parkinson’s and Alzheimer’s diseases, probiotics provide a novel therapeutic approach for neurodegenerative illnesses.
Alzheimer’s disease , gut microbiota , gut-brain axis , neurodegenerative disorders , prebiotics , Probiotics , synbiotics
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Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, UP,, Moradabad, 244001, India
Department of Pharmacy, Invertis University, UP,, Bareilly, 243123, India
Department of Medical Sciences, Kokshetau State Medical University, Kokshetau, 020009, Kazakhstan
Teerthanker Mahaveer College of Pharmacy
Department of Pharmacy
Department of Medical Sciences
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