Recent advances in the therapeutic potential of emodin for human health
Sharifi-Rad J. Herrera-Bravo J. Kamiloglu S. Petroni K. Mishra A.P. Monserrat-Mesquida M. Sureda A. Martorell M. Aidarbekovna D.S. Yessimsiitova Z. Ydyrys A. Hano C. Calina D. Cho W.C.
October 2022Elsevier Masson s.r.l.
Biomedicine and Pharmacotherapy
2022#154
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a bioactive compound, a natural anthraquinone aglycone, present mainly in herbaceous species of the families Fabaceae, Polygonaceae and Rhamnaceae, with a physiological role in protection against abiotic stress in vegetative tissues. Emodin is mainly used in traditional Chinese medicine to treat sore throats, carbuncles, sores, blood stasis, and damp-heat jaundice. Pharmacological research in the last decade has revealed other potential therapeutic applications such as anticancer, neuroprotective, antidiabetic, antioxidant and anti-inflammatory. The present study aimed to summarize recent studies on bioavailability, preclinical pharmacological effects with evidence of molecular mechanisms, clinical trials and clinical pitfalls, respectively the therapeutic limitations of emodin. For this purpose, extensive searches were performed using the PubMed/Medline, Scopus, Google scholar, TRIP database, Springer link, Wiley and SciFinder databases as a search engines. The in vitro and in vivo studies included in this updated review highlighted the signaling pathways and molecular mechanisms of emodin. Because its bioavailability is low, there are limitations in clinical therapeutic use. In conclusion, for an increase in pharmacotherapeutic efficacy, future studies with carrier molecules to the target, thus opening up new therapeutic perspectives.
Clinical trials , Emodin , Molecular mechanisms , Pharmacological properties , Signaling pathways
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Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile
Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco, 4811230, Chile
Department of Food Engineering, Faculty of Agriculture, Bursa Uludag University, 16059 Gorukle, Bursa, Turkey
Science and Technology Application and Research Center (BITUAM), Bursa Uludag University, 16059 Gorukle, Bursa, Turkey
Dipartimento di Bioscienze, Università degli Studi di Milano, via Celoria 26, Milano, 20133, Italy
Department of Pharmaceutical Chemistry, H.N.B. Garhwal (A Central) University, Uttarakhand, Srinagar Garhwal, 246174, India
Research Group in Community Nutrition and Oxidative Stress, University Research Institute of Health and Health Research Institute of Balearic Islands (IdISBa), University of the Balearic Islands-IUNICS, Palma de Mallorca, 07122, Spain
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, 4070386, Chile
Almaty Tecnological University, Kazakh-Russian Medical University, Almaty 050012, str. Tole bi 100, Str. Torekulova 71, Kazakhstan
Department of Biodiversity and Bioresource, Al-Farabi Kazakh National University, al-Farabi av. 71, Almaty, 050040, Kazakhstan
Biomedical Research Centre, Al-Farabi Kazakh National University, al-Farabi av. 71, Almaty, 050040, Kazakhstan
Department of Biological Chemistry, University of Orleans, Eure et Loir Campus, Chartres, 28000, France
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Facultad de Medicina
Departamento de Ciencias Básicas
Center of Molecular Biology and Pharmacogenetics
Department of Food Engineering
Science and Technology Application and Research Center (BITUAM)
Dipartimento di Bioscienze
Department of Pharmaceutical Chemistry
Research Group in Community Nutrition and Oxidative Stress
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN)
Department of Nutrition and Dietetics
Almaty Tecnological University
Department of Biodiversity and Bioresource
Biomedical Research Centre
Department of Biological Chemistry
Department of Clinical Pharmacy
Department of Clinical Oncology
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