Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
Sharifi-Rad J. Seidel V. Izabela M. Monserrat-Mequida M. Sureda A. Ormazabal V. Zuniga F.A. Mangalpady S.S. Pezzani R. Ydyrys A. Tussupbekova G. Martorell M. Calina D. Cho W.C.
December 2023BioMed Central Ltd
Cell Communication and Signaling
2023#21Issue 1
Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. [MediaObject not available: see fulltext.]
Apoptosis , Cancer , Cytotoxicity , Nrf2 , Oxidative stress , Phenolic compounds
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Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Natural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
Department of Advanced Material Technologies, Faculty of Chemistry, Wroclaw University of Science and Technology, Smoluchowskiego 25, Wroclaw, 50-372, Poland
Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands—IUNICS, Palma, 07122, Spain
Health Research Institute of Balearic Islands (IdISBa), Palma, 07120, Spain
CIBER Fisiopatología de La Obesidad Y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain
Department of Pharmacology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile
Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, Concepción, Chile
Department of Chemistry, NMAM Institute of Technology, Karnataka, Nitte, 574110, India
Phytotherapy Lab, Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Via Ospedale 105, Padova, 35128, Italy
AIROB, Associazione Italiana Per La Ricerca Oncologica Di Base, Padova, Italy
Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty, 050040, Kazakhstan
The Elliott School of International Affairs, George Washington University, 1957 E St NW, Washington, 20052, DC, United States
Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty, 050040, Kazakhstan
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile
Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción, 4070386, Chile
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Facultad de Medicina
Natural Products Research Laboratory
Department of Advanced Material Technologies
Research Group in Community Nutrition and Oxidative Stress
Health Research Institute of Balearic Islands (IdISBa)
CIBER Fisiopatología de La Obesidad Y Nutrición (CIBEROBN)
Department of Pharmacology
Department of Clinical Biochemistry and Immunology
Department of Chemistry
Phytotherapy Lab
AIROB
Biomedical Research Centre
The Elliott School of International Affairs
Department of Biophysics
Department of Nutrition and Dietetics
Universidad de Concepción
Department of Clinical Pharmacy
Department of Clinical Oncology
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