Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms
Sharifi-Rad J. Cruz-Martins N. López-Jornet P. Lopez E.P.-F. Harun N. Yeskaliyeva B. Beyatli A. Sytar O. Shaheen S. Sharopov F. Taheri Y. Docea A.O. Calina D. Cho W.C.
2021Hindawi Limited
Oxidative Medicine and Cellular Longevity
2021#2021
Coumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimers disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensive. There are very few studies on the bioavailability of coumarins; therefore, further investigations are necessitated to study the bioavailability of different coumarins which already showed good biological activities in previous studies. On the evidence of varied pharmacological properties, the present work presents an overall review of the derivation, availability, and biological capacities of coumarins with further consideration of the essential mode of their therapeutic actions. In conclusion, a wide variety of coumarins are available, and their pharmacological activities are of current interest thanks to their synthetic accessibility and riches in medicinal plants. Coumarins perform the valuable function as therapeutic agents in a range of medical fields.
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Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto, 4200-319, Portugal
Institute for Research and Innovation in Health (i3S), University of Porto, Porto, 4200-135, Portugal
Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra, 1317, PRD, Gandra, 4585-116, Portugal
Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca-UMU), Clínica Odontológica Universitaria Hospital Morales Meseguer, Adv. Marques de los Velez s/n, Murcia, 30008, Spain
Lahore College for Women University, Lahore, Pakistan
Al-Farabi Kazakh National University, Faculty of Chemistry and Chemical Technology, Almaty, 050040, Kazakhstan
University of Health Sciences, Department of Medicinal and Aromatic Plants, Istanbul, 34668, Turkey
Department of Plant Biology Department, Taras Shevchenko National University of Kyiv, Institute of Biology, Volodymyrska Str., 64, Kyiv, 01033, Ukraine
Department of Plant Physiology, Slovak University of Agriculture, Nitra, A. Hlinku 2, Nitra, 94976, Slovakia
Department of Plant Sciences, LCWU, Lahore, 54000, Pakistan
Research Institution Chinese-Tajik Innovation Center for Natural Products, Academy of Sciences of the Republic of Tajikistan, Ayni 299/2, Dushanbe, 734063, Tajikistan
Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Phytochemistry Research Center
Faculty of Medicine
Institute for Research and Innovation in Health (i3S)
Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU)
Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca-UMU)
Lahore College for Women University
Al-Farabi Kazakh National University
University of Health Sciences
Department of Plant Biology Department
Department of Plant Physiology
Department of Plant Sciences
Research Institution Chinese-Tajik Innovation Center for Natural Products
Department of Toxicology
Department of Clinical Pharmacy
Department of Clinical Oncology
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