Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
Sharifi-Rad J. Rapposelli S. Sestito S. Herrera-Bravo J. Arancibia-Diaz A. Salazar L.A. Yeskaliyeva B. Beyatli A. Leyva-Gómez G. González-Contreras C. Gürer E.S. Martorell M. Calina D.
September 2022MDPI
Journal of Personalized Medicine
2022#12Issue 9
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by a tangle-shaped accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The pathophysiological mechanism involves the presence of Aβ-amyloid peptide, Tau protein, oxidative stress, and an exacerbated neuro-inflammatory response. This review aims to offer an updated compendium of the most recent and promising advances in AD treatment through the administration of phytochemicals. The literature survey was carried out by electronic search in the following specialized databases PubMed/Medline, Embase, TRIP database, Google Scholar, Wiley, and Web of Science regarding published works that included molecular mechanisms and signaling pathways targeted by phytochemicals in various experimental models of Alzheimer’s disease in vitro and in vivo. The results of the studies showed that the use of phytochemicals against AD has gained relevance due to their antioxidant, anti-neuroinflammatory, anti-amyloid, and anti-hyperphosphorylation properties of Tau protein. Some bioactive compounds from plants have been shown to have the ability to prevent and stop the progression of Alzheimer’s.
Alzheimer’s disease , molecular mechanisms , neuroinflammation , neuroprotective effects , oxidative damage , phytochemicals , protein aggregation
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Facultad de Medicina, Universidad del Azuay, Cuenca, 14-008, Ecuador
Department of Pharmacy, University of Pisa, Via Bonanno 6, Pisa, 56126, Italy
Department of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, Sassari, 07100, Italy
Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Talca, 3460000, Chile
Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco, 4811230, Chile
School of Biochemical Engineering, Pontificia Universidad Catolica de Valparaiso, Av. Brasil 2085, Valparaiso, 2362803, Chile
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Medicinal and Aromatic Plants, University of Health Sciences, Istanbul, 34668, Turkey
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, 4070386, Chile
Department of Pharmacognosy, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Facultad de Medicina
Department of Pharmacy
Department of Chemistry and Pharmacy
Departamento de Ciencias Básicas
Center of Molecular Biology and Pharmacogenetics
School of Biochemical Engineering
Faculty of Chemistry and Chemical Technology
Department of Medicinal and Aromatic Plants
Departamento de Farmacia
Department of Nutrition and Dietetics
Department of Pharmacognosy
Department of Clinical Pharmacy
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