Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles
Sharifi-Rad J. Herrera-Bravo J. Semwal P. Painuli S. Badoni H. Ezzat S.M. Farid M.M. Merghany R.M. Aborehab N.M. Salem M.A. Sen S. Acharya K. Lapava N. Martorell M. Tynybekov B. Calina D. Cho W.C.
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Oxidative Medicine and Cellular Longevity
2022#2022
Artemisia plants are traditional and ethnopharmacologically used to treat several diseases and in addition in food, spices, and beverages. The genus is widely distributed in all continents except the Antarctica, and traditional medicine has been used as antimalarial, antioxidant, anticancer, antinociceptive, anti-inflammatory, and antiviral agents. This review is aimed at systematizing scientific data on the geographical distribution, chemical composition, and pharmacological and toxicological profiles of the Artemisia genus. Data from the literature on Artemisia plants were taken using electronic databases such as PubMed/MEDLINE, Scopus, and Web of Science. Selected papers for this updated study included data about phytochemicals, preclinical pharmacological experimental studies with molecular mechanisms included, clinical studies, and toxicological and safety data. In addition, ancient texts and books were consulted. The essential oils and phytochemicals of the Artemisia genus have reported important biological activities, among them the artemisinin, a sesquiterpene lactone, with antimalarial activity. Artemisia absinthium L. is one of the most famous Artemisia spp. due to its use in the production of the absinthe drink which is restricted in most countries because of neurotoxicity. The analyzed studies confirmed that Artemisia plants have many traditional and pharmacological applications. However, scientific data are limited to clinical and toxicological research. Therefore, further research is needed on these aspects to understand the full therapeutic potential and molecular pharmacological mechanisms of this medicinal species.
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Facultad de Medicina, Universidad Del Azuay, Cuenca, Ecuador
Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile
Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de la Frontera, Temuco, 4811230, Chile
Department of Life Sciences, Graphic Era Deemed to Be University, Uttarakhand, Dehradun, 248002, India
Uttarakhand Council for Biotechnology (UCB), Prem Nagar, Uttarakhand, Dehradun, 248007, India
Department of Biotechnology, School of Applied and Life Sciences, Uttaranchal University, Prem Nagar, Uttarakhand, Dehradun, 248007, India
Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, 12451, Egypt
Department of Phytochemistry and Plant Systematics, National Research Centre, 33 El Bohouth St., Dokki, P. O. 12622, Giza, Egypt
Pharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), 33 El-Bohouth street, Dokki, Giza, Egypt
Department of Biochemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, 12451, Egypt
Department of Pharmacognosy, Faculty of Pharmacy, Menoufia University, Gamal Abd El Nasr St., Shibin El Kom, Menoufia, 32511, Egypt
Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, 700019, India
Department of Botany, Fakir Chand College, West Bengal, Diamond Harbour, 743331, India
Medicine Standardization Department, Vitebsk State Medical University, Belarus
Department of Nutrition and Dietetics, Faculty of Pharmacy, And Centre for Healthy Living, University of Concepción, Concepción, Chile
Universidad de Concepción, Unidad de Desarrollo Tecnológico (UDT), Concepción, 4070386, Chile
Department of Biodiversity of Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Facultad de Medicina
Departamento de Ciencias Básicas
Center of Molecular Biology and Pharmacogenetics
Department of Life Sciences
Uttarakhand Council for Biotechnology (UCB)
Department of Biotechnology
Department of Pharmacognosy
Department of Pharmacognosy
Department of Phytochemistry and Plant Systematics
Pharmacognosy Department
Department of Biochemistry
Department of Pharmacognosy
Molecular and Applied Mycology and Plant Pathology Laboratory
Department of Botany
Medicine Standardization Department
Department of Nutrition and Dietetics
Universidad de Concepción
Department of Biodiversity of Bioresources
Department of Clinical Pharmacy
Department of Clinical Oncology
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