Unlocking the biological potential of methyl antcinate A: a new frontier in cancer and inflammation application
Sharif M. Irfan M. Kousar K. Mamurova A. Duarte-Peña L. Hernández-Parra H. Cortés H. Peña-Corona S.I. Khan K. Habtemariam S. Leyva-Gómez G. Sharifi-Rad J.
May 2025Springer Science and Business Media Deutschland GmbH
Naunyn-Schmiedebergs Archives of Pharmacology
2025#398Issue 54727 - 4745 pp.
Antrodia camphorata is a valued and scarce parasitic mushroom that exclusively proliferates on the inner cavity wall of the endangered tree Cinnamomum kanehirai Hay (Lauraceae), endemic to Taiwan. Historically, this fungus has been utilized in traditional medicine to treat liver cancer, diarrhea, abdominal pain, hypertension, and food and drug intoxication, among other ailments. Literature searches were performed in scientific databases. The results were compiled from peer-reviewed studies; the search was refreshed through January 2024 to incorporate the most recent research. In vitro studies have revealed that Antrodia camphorata possesses various pharmacological properties that prevent cancer, reduce inflammation, and improve liver function. This medicinal mushroom contains unique ergostane-type triterpenoids known as antcins, which exhibit numerous pharmacological properties. Seven naturally occurring methyl analogs of antcins have been identified so far. In this article, we reviewed and analyzed the properties of methyl antcinate A (MAA), a constituent of Antrodia camphorata and methyl derivative of antcin A. MAA has demonstrated important anti-apoptotic, anti-inflammatory, and gastro-protective properties, as well as significant anti-tumor, anti-cancer, and cytotoxic activities. The anti-cancer effect of MAA in various cancers is attributed to its ability to modulate signaling cascades in apoptotic pathways. A significant challenge is to initiate preclinical and clinical trials to assess its anti-tumor action in vivo, as this data is currently missing. Additionally, future research on the structure-activity relationship of antcins and their derivatives is expected to support their development as therapeutic agents for clinical use.
Anti-cancerous , Anti-inflammatory , Antrodia camphorata , Cytotoxic effect , Methyl antcinate A
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Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan
Cancer Clinical Research Unit, Trials360, Lahore, 54000, Pakistan
Department of Biodiversity of Bioresources, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico
Departamento de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Mexico City, Mexico
Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico
Pharmacognosy Research & Herbal Analysis Services UK, Central Avenue, Chatham-Maritime, Kent, ME4 4TB, United Kingdom
Departamento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico
Universidad Espíritu Santo, Samborondón, Ecuador
Centro de Estudios Tecnológicos y Universitarios del Golfo, Veracruz, Mexico
Department of Medicine, College of Medicine, Korea University, Seoul, 02841, South Korea
Atta-ur-Rahman School of Applied Biosciences (ASAB)
Cancer Clinical Research Unit
Department of Biodiversity of Bioresources
Departamento de Farmacia
Departamento de Farmacología
Laboratorio de Medicina Genómica
Pharmacognosy Research & Herbal Analysis Services UK
Departamento de Fisiología
Universidad Espíritu Santo
Centro de Estudios Tecnológicos y Universitarios del Golfo
Department of Medicine
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