CLINICAL RESEARCH OF PHOTODYNAMIC THERAPY WITH 5-ALA FOR CERVICAL INTRAEPITHELIAL NEOPLASMS: FROM PRELIMINARY STUDIES TO CURRENT DEVELOPMENTS

КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ ФОТОДИНАМИЧЕСКОЙ ТЕРАПИИ С 5-АЛК ПРИ ДИСПЛАЗИИ ШЕЙКИ МАТКИ: ОТ ПИЛОТНЫХ ИССЛЕДОВАНИЙ ДО СОВРЕМЕННЫХ РАЗРАБОТОК
Shanazarov N.A. Aitkaliyev A.D. Grishacheva T.G. Kissikova S.D. Zinchenko S.V. Kassiyeva B.S. Smailova S.B. Salmagambetova Zh.Zh. Seitbekova K.
2025 Russian Photodynamic Association

Biomedical Photonics
2025 #14 Issue 2 31 - 39 pp.

Non-surgical therapies are essential for reducing the progression rate of human papillomavirus-associated cervical intraepithelial neoplasia (CIN) from low-grade (CIN 1) to high-grade CIN (CIN 2/3) and subsequently to cervical cancer with minimal adverse reactions and complications in women, such as haemorrhaging, cervical stenosis, spontaneous abortion, and preterm birth. Photodynamic therapy (PDT) has garnered considerable attention as a non-invasive approach to CIN treatment in recent years. PDT works by applying photoactive compounds, known as photosensitizers, that accumulate in target cells. Subsequent exposure of these cells to light of a specific wavelength (photoactivation) occurs. This paper aims to review the clinical development of clinical research on the effectiveness of PDT with a 5-Aminolevulinic acid (5-ALA) photosensitiser for treating CIN 1-3 from the early preliminary studies to recent reports. Early PDT studies using lower concentrations of 5-ALA showed poor effectiveness, but recent research with a 20% concentration of 5-ALA demonstrated better outcomes. Larger studies, preferably conducted across multiple centres, are needed to establish the optimal number of PDT sessions required to eliminate HPV.

5-aminolevulinic acid , cervical intraepithelial neoplasia , human papillomavirus , photodynamic therapy , squamous intraepithelial lesions

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Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan
Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russian Federation
Kazan (Volga Region) Federal University, Kazan, Russian Federation

Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan
Pavlov First Saint-Petersburg State Medical University
Kazan (Volga Region) Federal University

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026