Alpha-lipoic Acid: An Antioxidant with Anti-aging Properties for Disease Therapy
Shanaida M. Lysiuk R. Mykhailenko O. Hudz N. Abdulsalam A. Gontova T. Oleshchuk O. Ivankiv Y. Shanaida V. Lytkin D. Bjørklund G.
2025Bentham Science Publishers
Current Medicinal Chemistry
2025#32Issue 123 - 54 pp.
The anti-aging effects of alpha-lipoic acid (αLA), a natural antioxidant synthe-sized in human tissues, have attracted a growing interest in recent years. αLA is a short-chain sulfur-containing fatty acid occurring in the mitochondria of all kinds of eukaryotic cells. Both the oxidized disulfide of αLA and its reduced form (dihydrolipoic acid, DHLA) exhibit prominent antioxidant function. The amount of αLA inside the human body gradually decreases with age resulting in various health disorders. Its lack can be compensated by supplying from external sources such as dietary supplements or medicinal dosage forms. The primary objectives of this study were the analysis of updated information on the latest two-decade research regarding the use of αLA from an anti-aging perspective. The information was collected from PubMed, Wiley Online Library, Scopus, ScienceDirect, SpringerLink, Google Scholar, and clinicaltrials.gov. Numerous in silico, in vitro, in vivo, and clinical studies revealed that αLA shows a protective role in biological systems by direct or indirect reactive oxygen/nitrogen species quenching. αLA demonstrated beneficial properties in the prevention and treatment of many age-related disorders such as neurodegeneration, metabolic disorders, different cancers, nephropathy, infertility, and skin senescence. Its preventive effects in case of Alzheimers and Parkinsons diseases are of particular interest. Further mechanistic and clinical studies are highly recommended to evaluate the wide spectrum of αLA therapeutic potential that could optimize its dietary intake for prevention and alleviation disorders related to aging.
atherosclerosis , cancer , chelating metals , detoxification , diabetes , dosage forms , Free radicals , infertility , nanoformulations , nephropathy , neurodegeneration , obesity , skin senescence
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I. Horbachevsky Ternopil National Medical University, Ternopil, 46001, Ukraine
CONEM Ukraine Natural Drugs Research Group, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Danylo Halytsky Lviv National Medical University, Lviv, 79010, Ukraine
Department of Research National University of Pharmacy, Kharkiv, 61168, Ukraine
Pharmacognosy and Phytotherapy Group, UCL School of Pharmacy, 29-39 Brunswick Square, London, WC1N 1AX, United Kingdom
CONEM Ukraine Bromatology and Medicinal Chemistry Group, National University of Pharmacy, Kharkiv, Ukraine
Department of Pharmacy and Ecological Chemistry, University of Opole, Opole, 45-052, Poland
Department of Research School of Medicine, Nazarbayev University, Astana, Kazakhstan
Department of Research Ternopil Ivan Puluj National Technical University, Ternopil, 46001, Ukraine
Department of Research Council for Nutritional and Environmental Medicine, Mo i Rana, 8610, Norway
I. Horbachevsky Ternopil National Medical University
CONEM Ukraine Natural Drugs Research Group
Danylo Halytsky Lviv National Medical University
Department of Research National University of Pharmacy
Pharmacognosy and Phytotherapy Group
CONEM Ukraine Bromatology and Medicinal Chemistry Group
Department of Pharmacy and Ecological Chemistry
Department of Research School of Medicine
Department of Research Ternopil Ivan Puluj National Technical University
Department of Research Council for Nutritional and Environmental Medicine
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