An Experimental Study on the Solubility of Betulin in the Complex Solvent Ethanol-DMSO
Shambilova G.K. Bukanova A.S. Kalauova A.S. Kalimanova D.Z. Abilkhairov A.I. Makarov I.S. Vinogradov M.I. Makarov G.I. Yakimov S.A. Koksharov A.V. Novikov E.M.
June 2024Multidisciplinary Digital Publishing Institute (MDPI)
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2024#12Issue 6
Betulin is a promising natural organic substance due to its antibacterial, fungicidal, and antitumor properties, as are their derivatives. The particle size of betulin can reach several tens of micrometers, and its thickness is several microns. There are various ways of processing betulin, but the most promising are solution methods (applying thin layers, impregnation, etc.). Application or impregnation of various materials is carried out using betulin; however, currently known solvents do not allow obtaining solutions with the necessary content of it. Since a number of direct solvents are already known for betulin, which provides only low-concentration solutions, the use of complex systems based on two solvents can become the optimal solution to the problem. The literature data show that the use of mixtures of solvents allows for the preparation of homogeneous solutions, for example, for natural polymers like cellulose, etc. This approach to obtaining solutions has become the basis for the processing of betulin. The use of a mixed solvent based on ethanol and DMSO for the preparation of betulin solutions has been proposed for the first time. The solubility of betulin in a mixture system with a ratio of components of 50 wt.% to 50 wt.% was studied, and a solubility curve was plotted. It is shown that the use of a two-component solvent makes it possible to transfer up to 10% of betulin into solution, which is almost twice as much as compared to already known solvents. The rheological properties of the obtained solutions have been studied. The viscosity of betulin solutions in a complex solvent depends on its content and temperature, so for 7% solutions at 70 °C, it is approximately 0.008 Pa*s. Applying betulin to the surface of the cardboard increases its hydrophobic properties and repellency.
betulin , complex solvent , DMSO , ethanol , morphology , rheology , solubility curve , solutions , temperature
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Institute of Petrochemical Engineering and Ecology named after N.K. Nadirov, Atyrau Oil and Gas University named after S. Utebayev, M, Baimukhanov Street, 45A, Atyrau, 060027, Kazakhstan
Department of Chemistry and Chemical Technology, Kh. Dosmukhamedov Atyrau University, Studenchesky Ave., 1, Atyrau, 060011, Kazakhstan
A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninsky Prospect, 29, Moscow, 119991, Russian Federation
Ilim Group, 42 Ul, Dybtsyna, Koryazhma, 165651, Russian Federation
Department of Chemistry, New Mexico Highlands University, Las Vegas, 87701, NM, United States
Institute of Petrochemical Engineering and Ecology named after N.K. Nadirov
Department of Chemistry and Chemical Technology
A.V. Topchiev Institute of Petrochemical Synthesis
Ilim Group
Department of Chemistry
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