Presepsin (soluble CD14 subtype) as a risk factor for the development of infectious and inflammatory complications in operated colorectal cancer patients

Shakeyev K. Turgunov Y. Ogizbayeva A. Avdiyenko O. Mugazov M. Grigolashvili S. Azizov I.
2022 Korean Society of Coloproctology

Annals of Coloproctology
2022 #38 Issue 6 442 - 448 pp.

Purpose: In this pilot study the dynamic of presepsin (soluble CD14 subtype, sCD14-ST) in blood serum was assessed as a possible risk factor for the development of systemic inflammatory response syndrome (SIRS) and infectious and inflammatory complications in operated colorectal cancer patients. Methods: To determine sCD14-ST by enzyme-linked immunosorbent assay method venous blood was taken 1 hour before surgery and 72 hours after it (3rd day). The presence of SIRS and organ dysfunctions (ODs) according to the Sequential Organ Failure Assessment scale were assessed. Results: Thiry-six patients with colorectal cancer were enrolled in the study. sCD14-ST level before surgery was 269.8±103.1 pg/mL (interquartile range [IQR], 196.7–327.1 pg/mL). Despite the presepsin level on the 3rd day being higher (291.1±136.5 pg/mL; IQR, 181.2–395.5 pg/mL), there was no statistical significance in its dynamics (P=0.437). sCD14-ST value both before surgery and on the 3rd day after it was significantly higher in patients with bowel obstruction (P=0.038 and P=0.007). sCD14-ST level before surgery above 330 pg/mL showed an increase in the probability of complications, SIRS, and OD (odds ratio [OR], 5.5; 95% confidence interval [CI], 1.1–28.2; OR, 7.0; 95% CI, 1.3–36.7; and OR, 13.0; 95% CI, 1.1–147.8; respectively). Patients with OD had higher levels on the 3rd day after surgery (P=0.049). Conclusion: sCD14-ST level in operated colorectal cancer patients was much higher if they were admitted with complication like bowel obstruction. Higher preoperative levels of sCD14-ST increase the probability of postoperative complications, SIRS, and OD. Therefore, further studies with large sample size are needed.

Colorectal neoplasms , Complications , Intestinal obstruction , sCD14-ST , Systemic inflammatory response syndrome

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Department of Surgical Diseases, NJSC “Karaganda Medical University,”, Karaganda, Kazakhstan
Collective Use Laboratory of the Research Center, NJSC “Karaganda Medical University,”, Karaganda, Kazakhstan
Department of Anesthesiology, Resuscitation and Emergency Medical Care, NJSC “Karaganda Medical University,”, Karaganda, Kazakhstan
Laboratory of National Research Institute of Antimicrobial Chemotherapy, Smolensk State Medical University, Smolensk, Russian Federation

Department of Surgical Diseases
Collective Use Laboratory of the Research Center
Department of Anesthesiology
Laboratory of National Research Institute of Antimicrobial Chemotherapy

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