Spatial-Division Multiplexing Approach for Simultaneous Detection of Fiber-Optic Ball Resonator Sensors: Applications for Refractometers and Biosensors
Shaimerdenova M. Ayupova T. Bekmurzayeva A. Sypabekova M. Ashikbayeva Z. Tosi D.
November 2022Multidisciplinary Digital Publishing Institute (MDPI)
Biosensors
2022#12Issue 11
Fiber-optic ball resonators are an attractive technology for refractive index (RI) sensing and optical biosensing, as they have good sensitivity and allow for a rapid and repeatable manufacturing process. An important feature for modern biosensing devices is the multiplexing capacity, which allows for interrogating multiple sensors (potentially, with different functionalization methods) simultaneously, by a single analyzer. In this work, we report a multiplexing method for ball resonators, which is based on a spatial-division multiplexing approach. The method is validated on four ball resonator devices, experimentally evaluating both the cross-talk and the spectral shape influence of one sensor on another. We show that the multiplexing approach is highly efficient and that a sensing network with an arbitrary number of ball resonators can be designed with reasonable penalties for the sensing capabilities. Furthermore, we validate this concept in a four-sensor multiplexing configuration, for the simultaneous detection of two different cancer biomarkers across a widespread range of concentrations.
ball resonators , biosensors multiplexing , cancer biomarkers , fiber-tip sensors , multiplexing , optical-fiber sensors , refractive index sensors , spatial-division multiplexing
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School of Engineering and Digital Sciences, Nazarbayev University, 53 Kabanbay Batyr, Astana, 010000, Kazakhstan
Department of Bioengineering, Nick Holonyak Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, 61801, IL, United States
National Laboratory Astana, Laboratory of Biosensors and Bioinstruments, 53 Kabanbay Batyr, Astana, 010000, Kazakhstan
School of Engineering and Computer Science, Baylor University, Waco, 76798, TX, United States
School of Engineering and Digital Sciences
Department of Bioengineering
National Laboratory Astana
School of Engineering and Computer Science
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