Therapeutic Potential of Ugonins: Bioactive Flavonoids from Helminthostachys zeylanica with Multifaceted Biological Activities
Shah A.B. Baiseitova A. Kim Y.J. Lee K.Y.
1 February 2026Georg Thieme Verlag
Planta Medica
2026#92Issue 2112 - 122 pp.
Ugonins are distinctive chemotaxonomic bioactive metabolites identified in Helminthostachys zeylanica. This uncommon fern species generates a diverse array of flavonoids, including ugonins, which facilitate various biological processes such as anti-inflammatory, neuroprotective, melanogenesis-inhibiting, antioxidant, anti-osteoporotic, and immunomodulatory functions. Our objective in this comprehensive literature review is to deliver a clear and visually engaging analysis of the therapeutic potential inherent in each of the compounds found in H. zeylanica. This review covers the isolation of ugonins A-Y and other metabolites from this plant. These compounds demonstrate a diverse range of biological properties, which are thoroughly discussed in this review. The binding scores of all ugonins A-Y against PTP1B were also presented, indicating their potential activities for future consideration. Ultimately, a thorough understanding of the diverse therapeutic properties inherent in this unique fern can be achieved through a meticulous examination of the existing literature.
anti-inflammatory , antidiabetic , antioxidant , Helminthostachys zeylanica , ophioglossaceae ugonins
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College of Pharmacy, Korea University, Sejong, South Korea
Interdisciplinary Major Program in Innovative Pharmaceutical Sciences, Korea University, Sejong, South Korea
The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Division of Applied Life Science (BK21 Four), IALS, Gyeongsang National University, Jinju, South Korea
College of Pharmacy
Interdisciplinary Major Program in Innovative Pharmaceutical Sciences
The Research Center for Medicinal Plants
Division of Applied Life Science (BK21 Four)
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Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026