Evaluation of purine metabolites after coronary artery bypass grafting in overweight and normal-weight patients

Оценка метаболитов пуринового обмена после аортокоронарного шунтирования у пациентов с избыточной и нормальной массой тела
Seytekova A.N. Molotov-Luchansky V.B. Ponomareva O.A. Mershenova G.Z. Ekizhanova B.T. Visternichyan O.A. Shaukhat D.M. Zhumabekova I.K. Beynikova I.V. Aitisheva L.B. Auasheva A.B. Kosybaeva M.E. Myrzashova N.B. Dildabekova A.S.
2025 Silicea-Poligraf

Cardiovascular Therapy and Prevention (Russian Federation)
2025 #24 Issue 10

Aim. To study the purine metabolism changes in overweight patients who underwent coronary artery bypass grafting (CABG) in the early postoperative period and during the rehabilitation, compared with that in patients with normal body weight. Material and methods. This prospective study included 155 patients, including 87 (56%) men and 68 (44%) women, who underwent CABG due to critical coronary artery stenosis. All patients were diagnosed with single-vessel disease. The age range was 35-65 years. Patients were divided into 3 following groups: group 1 (n=85) — overweight patients; group 2 (n=70) — patients with normal body weight; group 3 (control group) — 30 healthy individuals. Changes in purine metabolite levels were assessed over time: 1 day after blood flow restoration at the cardiac surgery center, and then at rehabilitation stages 1 (1 to 3 months), 2 (3 to 6 months), and 3 (6 months to 1 year) at the cardiac reha bilitation center. Statistical analysis was performed using SPSS 27.0 and MedCalc version 22 software. The data are presented as tables and graphs using GraphPad PrismTM (version 7). Results. In overweight patients after CABG, purine metabolite levels initially decrease, including in rehabilitation stages 1 and 2, and then sharply increase in rehabilitation stage 3. Conclusion. In overweight patients, the level of purine metabolites increases sharply after CABG at rehabilitation stage 3 compared to those at stages 1 and 2, suggesting resumption of the pathological process (ischemia, inflammation).

coronary artery bypass grafting , overweight , purine metabolites

Text of the article Перейти на текст статьи

Karaganda Medical University, Karaganda, Kazakhstan
Cardic Rehabilitation Center Tulpar, Karaganda, Kazakhstan
Astana Medical University, Astana, Kazakhstan

Karaganda Medical University
Cardic Rehabilitation Center Tulpar
Astana Medical University

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026