Anticancer potential of decursin, decursinol angelate, and decursinol from Angelica gigas Nakai: A comprehensive review and future therapeutic prospects
Sestito S. Ibba R. Riu F. Carpi S. Carta A. Manera C. Habtemariam S. Yeskaliyeva B. Almarhoon Z.M. Sharifi-Rad J. Rapposelli S.
October 2024John Wiley and Sons Inc
Food Science and Nutrition
2024#12Issue 106970 - 6989 pp.
Many naturally derived compounds are currently used in oncotherapy. Besides official medicine, complementary and alternative medicine practices, including old herbal remedies, are widely used and accepted as additional tools in cancer treatment. Angelica gigas Nakai (AGN), a medicinal herb in Asia, has roots historically used in medicine. This review focuses on key bioactive compounds from AGN roots – decursin, decursinol angelate (DA), and decursinol (DOH). Exploring their source, biosynthesis, and therapeutic mechanisms, the review highlights their role in cancer treatment. Biotechnological strategies for enhanced production and semisynthetic derivatives with anticancer properties are discussed. The study emphasizes the promising pharmacological potential of decursin, DA, and DOH in various therapeutic applications, particularly cancer treatment. The review also underscores innovative approaches to increase production and explores semisynthetic derivatives as a promising avenue for future natural product-based drug discovery. This concise overview provides valuable insights into the potential of AGN-derived compounds in the field of natural product-based therapeutics.
anticancer , decursin , decursinol , natural product , traditional medicine
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Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, Sassari, Italy
Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy
Department of Chemistry−BMC, Uppsala University, Uppsala, Sweden
NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Pisa, Italy
Department of Health Sciences, University ‘Magna Græcia’ of Catanzaro, Catanzaro, Italy
Department of Pharmacy, University of Pisa, Pisa, Italy
Pharmacognosy Research & Herbal Analysis Services UK, University of Greenwich, Kent, United Kingdom
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, South Korea
Centro de Estudios Tecnológicos y Universitarios del Golfo, Veracruz, Mexico
Department of Chemical
Department of Medicine
Department of Chemistry−BMC
NEST
Department of Health Sciences
Department of Pharmacy
Pharmacognosy Research & Herbal Analysis Services UK
Faculty of Chemistry and Chemical Technology
Department of Chemistry
Department of Biomedical Sciences
Centro de Estudios Tecnológicos y Universitarios del Golfo
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