The Role of Exosomes in Cancer Progression and Therapy
Sergazy S. Seydahmetova R. Gulyayev A. Shulgau Z. Aljofan M.
January 2025Multidisciplinary Digital Publishing Institute (MDPI)
Biology
2025#14Issue 1
Exosomes are small particles released by cells and involved in cellular communication. In cancer, they carry signals from tumor cells to other cells, encouraging cancer to grow and spread. This review describes how exosomes play two opposing roles at the same time, consisting of how they contribute to cancer progression and how they might be used to treat cancer in new ways. On the one hand, tumor-derived exosomes carry certain molecules that alter adjacent cells to support the tumor, help cancerous cells move to other parts of the body, and avoid the defense of the immune system. On the other hand, exosomes could be used as a suitable means to deliver cancer-fighting drugs directly to tumor cells, making treatment more targeted and potentially reducing side effects. However, a number of challenges could slow down their development into useful medical tools. Thus, this work aims to describe exosomes, their components, and the current challenges for their future use.
cancer therapy , drug delivery , exosomes , extracellular vesicles , tumor microenvironment , tumor-derived exosomes
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LLP VICTUS PHARM, 010000, Astana, Kazakhstan
National Laboratory Astana, Center for Life Sciences, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, 010000, Kazakhstan
LLP VICTUS PHARM
National Laboratory Astana
Department of Biomedical Sciences
10 лет помогаем публиковать статьи Международный издатель
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