Blueberry and cranberry extracts mitigate CCL4-induced liver damage, suppressing liver fibrosis, inflammation and oxidative stress
Sergazy S. Shulgau Z. Kamyshanskiy Y. Zhumadilov Z. Krivyh E. Gulyayev A. Aljofan M.
April 2023Elsevier Ltd
Heliyon
2023#9Issue 4
The current study aims to evaluate potential hepatoprotective effect of lingonberry, cranberry and blueberry polyphenols on carbon tetrachloride (CCL-4)-induced acute and subacute liver injury in rats. A total of 55 male Wistar rats, divided into six experimental and control groups. With the exception of the negative control group, all groups received an intraperitoneal injection of CCl-4, twice a week for 14 days. An extract of lingonberry, cranberry, blueberry polyphenols and the positive control, silymarin were administered daily via intragastric route, for 14 consecutive days. The untreated control group showed characteristic of classical oxidative stress-mediated liver damage with vacuolization of the hepatocyte cytoplasm, infiltration by immune cells and proliferation of collagen fibers, decrease in body weight and increase in liver weight; increased levels of AST and ALT in serum, an increased lipid peroxidation in the liver. However, the use of cranberry and blueberry polyphenols significantly suppressed liver damage, exerting an effect comparable to the hepatoprotective effect of the positive control. The extracts prevented and reduced inflammatory liver damage by reducing IL-6, TNF-α and IFN-γ levels. In conclusion, blueberry and cranberry extracts have a protective effect against acute and subacute CCl4-induced hepatotoxicity in rats.
Antioxidant , Liver fibrosis , Polyphenol , ROS
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National Center for Biotechnology, Astana, Kazakhstan
National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan
Clinic of Medical University “MUK” NCJSC, Karaganda, Kazakhstan
Khanty-Mansiysk State Medical Academy, Khanty-mansiysk, Russian Federation
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, 010000, Kazakhstan
National Center for Biotechnology
National Laboratory Astana
Clinic of Medical University “MUK” NCJSC
Khanty-Mansiysk State Medical Academy
Department of Biomedical Sciences
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