Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines
Sergazy S. Vetrova A. Orhan I.E. Senol Deniz F.S. Kahraman A. Zhang J.-Y. Aljofan M.
February 2022Future Medicine Ltd.
Future Science OA
2022#8Issue 2
Aim: To determine the antiproliferative and cytotoxic activities of Geranium and Erodium species against human cancer and noncancer cell lines, respectively. Methods: Twenty-one species of Geranium and Erodium were extracted and screened against cancerous and noncancerous human cell lines. Results: In a dose-response manner, G. glaberrimum, G. asphodeloides, E. brandianum and E. leucanthum were able, with variable potency, to inhibit cellular proliferation. Except for E. brandianum, all extracts induced cellular autophagy in tumor cells with similar levels to that of rapamycin; but, only E. brandianum induced cellular apoptosis, likely through Bcl2 and BAX protein expressions. Discussion: This is the first study to report the potential antiproliferative effects of ethanol extracts of several Geraniaceae species.
anticancer , antiproliferative , breast cancer , cytotoxicity , Erodium , Geraniaceae , Geranium
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National Laboratory Astana, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan
Department Of Biomedical Science, Nazarbayev University School Of Medicine, Nur-Sultan, 010000, Kazakhstan
Department Of Pharmacognosy, Gazi University, Ankara, 06330, Turkey
Department Of Biology, Usak University, Usak, 64200, Turkey
Key Lab. Of Molec. Target And Clin. Pharmacology And The State Key Laboratory Of Respiratory Disease, School Of Pharmaceutical Sciences And The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
National Laboratory Astana
Department Of Biomedical Science
Department Of Pharmacognosy
Department Of Biology
Key Lab. Of Molec. Target And Clin. Pharmacology And The State Key Laboratory Of Respiratory Disease
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