Antimicrobial Resistance and the Blood–Brain Barrier: Complex Interactions and Implications for Neurological Health
Semenova Y. Dadar M. Makalkina L. Lim L. Bjørklund G.
January 2026Springer
Molecular Neurobiology
2026#63Issue 1
This review explores the interplay between antimicrobial resistance (AMR) and the blood–brain barrier (BBB) and its potential implications for neurological health. It encompasses diverse facets, from the mechanisms used by pathogens to cross the BBB to the clinical outcomes and long-term consequences of compromised BBB integrity. The analysis underscores the complexity of this relationship, revealing how AMR challenges treatment efficacy while the BBB acts as a crucial guardian of central nervous system (CNS) homeostasis. Both direct and indirect mechanisms exist through which pathogens impact the BBB, including structural compromise and the elicitation of neuroinflammatory responses. These interactions have profound implications for the incidence, severity, and prognosis of CNS infections. A novel contribution of this review is its discussion of emerging evidence linking AMR to neurodegenerative processes, as well as its consideration of advanced diagnostic and therapeutic strategies.
Antimicrobial resistance , Antimicrobials , Blood–brain barrier , Central nervous system , Neuroinflammation , Neurological health , Pathogens
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Nazarbayev University, Astana, Kazakhstan
CONEM International Microbiology Research Group, Paris, France
Astana Medical University, Astana, Kazakhstan
Council for Nutritional and Environmental Medicine (CONEM), Toften 24, Mo I Rana, 8610, Norway
Nazarbayev University
CONEM International Microbiology Research Group
Astana Medical University
Council for Nutritional and Environmental Medicine (CONEM)
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026