A Nationwide Evaluation of Antibiotic Consumption in Kazakhstan from 2019 to 2023
Semenova Y. Yergaliyeva A. Aimurziyeva A. Manatova A. Kuntuganova A. Makalkina L. Aldiyarova N. Semenov D. Lim L.
December 2024Multidisciplinary Digital Publishing Institute (MDPI)
Antibiotics
2024#13Issue 12
Background/Objectives: There has been a lack of a holistic approach to evaluating antibiotic consumption in Kazakhstan over the past few years using an internationally recognized methodology. Therefore, this study aimed to provide a nationwide evaluation of antibiotic consumption in Kazakhstan during the period 2019–2023. Methods: Defined daily doses per 1000 inhabitants per day (DIDs) were calculated for systemic antibiotics (J01 code of the Anatomical Therapeutic Chemical Classification System (ATC)) following the methodology established by the Global Antimicrobial Resistance and Use Surveillance System (GLASS-AMC). The average annual percent change (AAPC) was computed for each chemical agent, pharmacological group, and J01 in general to evaluate past trends in antibiotic consumption. Results: The consumption of J01 antibiotics ranged between 10.869 DIDs (2022) and 14.470 DIDs (2020). There was an increase in antibiotic consumption during 2020 and 2021, but the overall trend was declining, with an AAPC of −2.45%. Azithromycin was the most consumed systemic antibiotic, followed by ceftriaxone and ciprofloxacin. The consumption of “Watch” group antibiotics prevailed in Kazakhstan during the study period, with the number of people consuming the top five “Watch” group antibiotics rising from 72,578 in 2019 to 94,617 in 2023. Conclusions: The findings of this study are crucial for the reorganization of the national antimicrobial stewardship program.
antibiotic consumption , antimicrobial resistance , antimicrobial stewardship , defined daily doses , Kazakhstan
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Department of Surgery, School of Medicine, Nazarbayev University, Astana, 010000, Kazakhstan
National Center of Public Healthcare, Astana, 010000, Kazakhstan
School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan
National Scientific Center for Oncology and Transplantation, Astana, 020000, Kazakhstan
Department of Clinical Pharmacology, Astana Medical University, Astana, 010000, Kazakhstan
Professional Association of Clinical Pharmacologists and Pharmacists, Astana, 010000, Kazakhstan
Computer Science and Engineering Program, Astana IT University, Astana, 010000, Kazakhstan
Graduate School of Public Policy, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Surgery
National Center of Public Healthcare
School of Sciences and Humanities
National Scientific Center for Oncology and Transplantation
Department of Clinical Pharmacology
Professional Association of Clinical Pharmacologists and Pharmacists
Computer Science and Engineering Program
Graduate School of Public Policy
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