Sensitive detection of kidney injury biomarker (KIM1) in urine samples using an optical fiber semi-distributed interferometer biosensor
Seitkamal K. Afroz A. Tleuzhanova A. Makhammajanov Z. Kumar S. Gaipov A. Blanc W. Tosi D. Bekmurzayeva A.
1 December 2025Elsevier B.V.
Talanta
2025#295
Kidney injury molecule 1 (KIM-1) is a promising biomarker for early diagnosis of various kidney diseases such as acute kidney injury and chronic kidney disease. This study introduces a fiber-optic biosensor based on a semi-distributed interferometer (SDI) designed for direct measurement of KIM-1 in human urine specimens. The biosensor demonstrated exceptional sensitivity and specificity to KIM1 protein, and the KIM-1-functionalized sensor significantly surpassed the control sensors with optimal responses in both artificial and abnormal urine samples. The response of the SDI biosensor to KIM-1 in clinical samples showed a linear range from 10 aM to 1 nM, covering concentrations between 1 aM and 100 nM. The lowest limit of detection is 13.6 aM with an exceptional accuracy. Clinical testing confirmed the biosensors high selectivity, sensitivity, and stability, positioning it as a promising non-invasive diagnostic tool for early detection and monitoring of kidney diseases.
Kidney diseases , KIM1 detection , Optical fiber biosensors , Semi-distributed interferometer , Surface functionalization , Urine-based diagnostics
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Laboratory of Biosensors and Bioinstruments, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan
School of Engineering and Digital Sciences, Nazarbayev University, Astana, Kazakhstan
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Centre of Excellence for Nanotechnology, Department of Electronics and Communication Engineering, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, Vaddeswaram, India
Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Université Côté dAzur, CNRS, INPHYNI, France
Laboratory of Biosensors and Bioinstruments
School of Engineering and Digital Sciences
Department of Biomedical Sciences
Centre of Excellence for Nanotechnology
Department of Medicine
Université Côté dAzur
10 лет помогаем публиковать статьи Международный издатель
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