Influence of Chain Length of Gradient and Block Copoly(2-oxazoline)s on Self-Assembly and Drug Encapsulation
Sedlacek O. Bardoula V. Vuorimaa-Laukkanen E. Gedda L. Edwards K. Radulescu A. Mun G.A. Guo Y. Zhou J. Zhang H. Nardello-Rataj V. Filippov S. Hoogenboom R.
April 27, 2022John Wiley and Sons Inc
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2022#18Issue 17
Amphiphilic gradient copolymers represent a promising alternative to extensively used block copolymers due to their facile one-step synthesis by statistical copolymerization of monomers of different reactivity. Herein, an in-depth analysis is provided of micelles based on amphiphilic gradient poly(2-oxazoline)s with different chain lengths to evaluate their potential for micellar drug delivery systems and compare them to the analogous diblock copolymer micelles. Size, morphology, and stability of self-assembled nanoparticles, loading of hydrophobic drug curcumin, as well as cytotoxicities of the prepared nanoformulations are examined using copoly(2-oxazoline)s with varying chain lengths and comonomer ratios. In addition to several interesting differences between the two copolymer architecture classes, such as more compact self-assembled structures with faster exchange dynamics for the gradient copolymers, it is concluded that gradient copolymers provide stable curcumin nanoformulations with comparable drug loadings to block copolymer systems and benefit from more straightforward copolymer synthesis. The study demonstrates the potential of amphiphilic gradient copolymers as a versatile platform for the synthesis of new polymer therapeutics.
gradient copolymers , nanomedicine , poly(2-oxazoline)s , self-assembly
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Supramolecular Chemistry Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4, Ghent, B-9000, Belgium
Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova, 2030, Prague 2, 128 40, Czech Republic
Centrale Lille, Université de Lille, CNRS, Université Artois, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide, Lille, F-59000, France
Tampere University of Technology, Korkeakoulunkatu 7, Tampere, 33720, Finland
Department of Chemistry –Ångström Laboratory, Uppsala University, Lägerhyddsvägen 1, Uppsala, Sweden
Jülich Centre for Neutron Science (JCNS) at Heinz Maier-Leibnitz Zentrum (MLZ) Forschungszentrum Jülich GmbH, Lichtenbergstr. 1, Garching, 85748, Germany
Department of Chemistry & Technology of Organic Materials, Polymers and Natural Compounds, al Faraby Kazakh National University, 71, al-Faraby av., Almaty, 050040, Kazakhstan
Department of Endocrinology, Key Laboratory of National Health & Family Planning Commission for Male Reproductive Health, National Research Institute for Family Planning, Beijing, 100081, China
Pharmaceutical Sciences Laboratory and Turku Bioscience Center, of Åbo Akademi University and Turku Bioscience, Turku, 20520, Finland
Experimental Hematology and Biochemistry Lab, Beijing Institute of Radiation Medicine, Beijing, 100850, China
School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6DX, United Kingdom
Supramolecular Chemistry Group
Department of Physical and Macromolecular Chemistry
Centrale Lille
Tampere University of Technology
Department of Chemistry –Ångström Laboratory
Jülich Centre for Neutron Science (JCNS) at Heinz Maier-Leibnitz Zentrum (MLZ) Forschungszentrum Jülich GmbH
Department of Chemistry & Technology of Organic Materials
Department of Endocrinology
Pharmaceutical Sciences Laboratory and Turku Bioscience Center
Experimental Hematology and Biochemistry Lab
School of Pharmacy
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