Magnetic CNTs/MnO2/chitin nanocomposite for preconcentration and detection of trace narcotics in biological samples using D-μ-SPE method


Sedaghat Y. Rajabi M. Asghari A. Silerio-Vázquez F.D.J. Galiya F. Naseri A. Hosseini-Bandegharaei A.
August 2026Elsevier B.V.

Talanta Open
2026#13

This study reports successful synthesis and application of a multifunctional magnetic nanocomposite, comprising MWCNTs, MnO₂, and mealworm skin-extracted chitin, as a splendid sorbent for preconcentration and determination of narcotic drugs papaverine, noscapine, codeine, and morphine in complex biological matrices, using d -μ-SPE (dispersive micro-solid-phase extraction). Characterization via FT-IR, FE-SEM, XRD, EDS, TGA, VSM, and BET analyses confirmed the nanocomposites structural integrity, high surface area (107.68 m²/g), mesoporosity, and superparamagnetic behaviour, which altogether enhance adsorption capacity and facilitate facile and rapid magnetic separation. Adsorption studies demonstrated adherence to Langmuir and pseudo-second-order models, indicative of monolayer adsorption on homogeneous active sites. Statistical optimization using Central Composite Design allowed precise modulation of parameters influencing adsorption and desorption phases, improving extraction recoveries and method reproducibility. Optimal conditions for maximum analyte recovery within short extraction and desorption times included a sample pH around neutrality (7.3), adsorbent dosage of 5.8 mg, and the usage of a 50:50 ethanol-acetonitrile solvent mixture for desorption. With LODs as low as 0.10 ng/mL, broad linear dynamic ranges, and relative standard deviations under 4.8 %, the method exhibited remarkable analytical performance. Application to real samples, including plasma, breast milk, urine, and saliva, yielded recoveries between 93.36 % and 102.85 %, which vouchsafed robustness and minimal matrix interference. Overall, exploiting a novel magnetic nanocomposite, the new environmentally-compatible, rapid, and sensitive UA-D-μ-SPE method offers a powerful tool for trace-level detection of narcotic drugs, leading to enhanced capabilities in forensic and clinical toxicology.

Adsorption properties , Dispersive micro-solid phase extraction , Green synthesis , Nanocomposite , Narcotics

Text of the article Перейти на текст статьи

Department of Chemistry, Semnan University, Semnan, Iran
CIIDIR-Durango, Instituto Politécnico Nacional, Calle Sigma 119, Fraccionamiento 20 de Noviembre II, C. P.,, Durango, 34220, Mexico
Department of Pharmaceutical Disciplines, Astana Medical University, Astana, Kazakhstan
Department of Medical Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Sustainable Engineering, Saveetha School of Engineering, SIMATS, Tamil Nadu, Chennai, -602105, India
Scientific Research Center, Al-Ayen Iraqi University (AUIQ), Thi-Qar, Nasiriyah, 64001, Iraq

Department of Chemistry
CIIDIR-Durango
Department of Pharmaceutical Disciplines
Department of Medical Parasitology and Mycology
Department of Sustainable Engineering
Scientific Research Center

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026