Metabolomics in Search of Noninvasive Biomarkers for Allograft Rejection in Pediatric Kidney Transplantation
Sazonov V. Zhailauova A. Altynova S. Bayanova M. Daniyarova G. Bolatov A. Pya Y.
2024National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2024#21Issue 611 - 17 pp.
Introduction: Kidney transplantation is recognized as the most effective treatment for children with end-stage renal disease (ESRD), providing significant improvements in quality of life and long-term survival. Traditional methods to detect involve after allograft rejection AR primarily invasive biopsy procedures that, while diagnostic, carry significant risks, especially in pediatric patients. Therefore, there is an urgent need for safer, less invasive, and more patient-f riendly methods to monitor graft health. Metabolomics, the comprehensive analysis of small-molecule metabolites within a biological sample, offers a promising solution. Materials and Methods: This paper is a non-systematic review. PubMed and Scopus-indexed journals were used to collect articles for research. In general, 6 papers were included. Results: Our findings indicate that specific urinary metabolites can serve as sensitive and specific indicators of AR, offering a safer alternative to biopsies. Metabolomic profiling not only provides real-time insights into graft health, but also supports personalized management strategies to improve patient outcomes. This study contributes to the evolving field of transplant diagnostics, demonstrating how non-invasive methods such as metabolomics could revolutionize the monitoring and treatment of pediatric kidney transplant recipients.
biomarkers , kidney transplantation , Metabolomics , pediatrics , rejection
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Department of Surgery, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Research Department, Corporate Fund “University Medical Center”, Astana, Kazakhstan
Medical and Regulatory Affairs Department, Corporate Fund “University Medical Center”, Astana, Kazakhstan
Department of Clinical and Genetic Diagnostics, CAD of Laboratory Medicine, Pathology and Genetics, Corporate Fund “University Medical Center”, Astana, Kazakhstan
Corporate Fund “University Medical Center”, Astana, Kazakhstan
Doctoral program, Shenzhen University, Shenzhen, China
Department of Surgery
Research Department
Medical and Regulatory Affairs Department
Department of Clinical and Genetic Diagnostics
Corporate Fund “University Medical Center”
Doctoral program
10 лет помогаем публиковать статьи Международный издатель
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