Case Series: Efficacy and Safety of Hemoadsorption With HA-330 Adsorber in Septic Pediatric Patients With Cancer
Sazonov V. Abylkassov R. Tobylbayeva Z. Saparov A. Mironova O. Poddighe D.
11 June 2021Frontiers Media S.A.
Frontiers in Pediatrics
2021#9
Background: Sepsis is a frequent cause of death in hospitalized patients and, in detail, in neonatal, pediatric, and adult intensive care units (ICUs). Severe sepsis has a very poor prognosis. Indeed, the mortality rate varies between 30 and 70% during the first 7–14 days. Despite a timely and appropriate therapy, the prognosis of severe sepsis is too often negative. Therefore, new therapeutic resources are under investigation in order to further improve prognosis. Case series: Here, we reported three septic children in whom we used extracorporeal blood purification therapy with hemoadsorption device HA330 (Jafron Biomedical Co., Ltd., China), aiming to scavenge and eliminate bacterial toxins and inflammatory mediators from the blood. Discussion and Conclusion: This small case series first showed that hemoperfusion with HA330 cartridge may be an effective and relatively safe adjunctive treatment to counterbalance the cytokine storm in septic children with hematological disorders. Further studies are needed to confirm and further support its safety and efficacy in a large number of pediatric patients. © Copyright
blood purification , HA-330 adsorber , hemoadsorption , pediatric cancer , sepsis
Text of the article Перейти на текст статьи
Department of Biomedical Sciences, Nazarbayev University School of Medicine, Nur-Sultan, Kazakhstan
Pediatric Anesthesiology and Intensive Care Unit, National Research Center for Maternal and Child Health, “University Medical Center”, Nur-Sultan, Kazakhstan
Department of Medicine, Nazarbayev University School of Medicine, Nur-Sultan, Kazakhstan
Department of Pediatrics, National Research Center for Maternal and Child Health, “University Medical Center”, Nur-Sultan, Kazakhstan
Department of Biomedical Sciences
Pediatric Anesthesiology and Intensive Care Unit
Department of Medicine
Department of Pediatrics
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026