Antibodies to Hepatitis B core antigen prevalence study in Kazakhstan

Savchuk T. Grinvald Y. Ali M. Sepetiene R. Saussakova S. Zhangazieva K. Imashpayev D. Abdrakhmanova S.
March 2023 John Wiley and Sons Inc

Immunity, Inflammation and Disease
2023 #11 Issue 3

Introduction: Kazakhstan is being considered medium-endemic for Hepatitis B virus infection (HBV). HBV remains transmissible by direct exposure to infected blood or organic fluids. This cross-sectional study aimed to evaluate the prevalence of anti-HBcore and the risk factors impacting positive anti-HBcore markers among donors at Scientific-Production Center of Transfusiology, Ministry of Healthcare of the Republic of Kazakhstan. Materials and Methods: The samples taken from blood donors were tested for anti-HBcore, by the chemiluminescence immunoassay method on the Architect i2000SR (Abbott). In case of positive anti-HBcore, the blood samples were further tested for anti-HBs on the Architect i2000SR (Abbott). Alanine aminotransferase (ALT) indicators were tested by kinetic method on the Biosystems A25 analyzer. Statistical analysis was conducted using R software (version 4.1.1, 2021). Results: Five thousand seven hundred and nine people aged 18–66 years included in the study, the proportion of men and women was 68.17% and 31.83%, respectively. The average age of the participants was 35.7 ± 10.57 years. The prevalence of anti-HBcore among donors was 17.2% (983). Among participants with elevated ALT (170), this marker was determined in 23%, and for donors with normal levels of ALT (5539)−17%. Participants with positive anti-HBcore scores were on average older (41.8 vs. 34.4 years, p <.001) and Kazakhs (88.7% vs. 83.0%, p <.001) by nationality than study participants with negative results of anti-HBcore. Conclusions: Anti-HBcore prevalence in Kazakhstan (17.2%) compared with other countries (Croatia 7%, France 7%, Germany 9%, Iran 16%, Malaysia 20%, respectively) remains above average. Given the prevalence of HBV and risk factors, it is recommended to include an additional anti-HBcore marker in the mandatory screening of donated blood in the Kazakhstan Republic and improve preventive measures to prevent HBV transmission by blood transfusions.

blood donors’ virology markers , occult Hepatitis B , positive anti-HBcor , prevalence of anti-HBcor

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Scientific-Production Center of Transfusiology, Nur-Sultan, Kazakhstan
Abbott Laboratories GmbH, Dubai, United Arab Emirates
Abbott GmbH Max-Planck-Ring 2, Wiesbaden, Germany
Department of Public Health, Astana Medical University, Nur-Sultan, Kazakhstan

Scientific-Production Center of Transfusiology
Abbott Laboratories GmbH
Abbott GmbH Max-Planck-Ring 2
Department of Public Health

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