Health-Related Quality of Life in Patients with Chronic Hepatitis B: A Meta-Analysis of Observational Studies

Saussakova S. Dauletova G. Nakipov Z. Sarsenbayeva G. Duisekova S. Sadibekova Z. Raissova K. Turgambayeva A.
2023 Tehran University of Medical Sciences

Iranian Journal of Public Health
2023 #52 Issue 3 453 - 462 pp.

Background: Chronic hepatitis B virus (CHB) infection is one of the most common liver infections worldwide. Approximately 240 million patients are diagnosed with CHB. The objective of this meta-analysis was to identify the effect of CHB on the affected patients’ health-related quality of life and com-pare with the control group. Methods: A comprehensive search was conducted through PubMed, Medline, ProQuest, Cochrane Central Register of Controlled Trials, Clinicaltrials.gov, and Web of Science databases up to Jul 2022. Results: Five primary observational studies using SF-36 and WHOQOL surveys with 1135 participants (646 with CHB and 489 healthy individuals) included in the meta-analysis. We evaluated the scores of physical and mental component summaries. HRQoL was comparable in both groups. The diseases impact ap-pears to slightly affect the mental component summary than the physical component summary. Conclusion: The HRQoL in CHB patients is mainly reflected in the impairment of the mental aspect. It is vital to focus on optimally managing care, family and social support, stress management.

Chronic hepatitis B patients , Health-related quality of life , Meta-analysis , Quality of life

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Department of Public Health and Management, NJSC “Astana Medical University”, Astana, Kazakhstan
Department of Medical Insurance and Public Health, South Kazakhstan Medical Academy, Shymkent, Kazakhstan
Department of Social Health Insurance and Public Health, South Kazakhstan Medical Academy, Shymkent, Kazakhstan

Department of Public Health and Management
Department of Medical Insurance and Public Health
Department of Social Health Insurance and Public Health

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