Synergistic Role of MoO₃–CTAB Nanostructures in Boosting Electrochemical Immunosensing of HER2

Sarsenbayeva A. Kudreyeva L. Sadak S. Abu M. Toleukhan A. Uslu B.
10 February 2026 Elsevier Ltd

Electrochimica Acta
2026 #549

Cancer is a disease that impacts a significant portion of the global population, and delayed diagnosis complicates treatment and elevates mortality rates. The disease affects many organs and has many subtypes. Breast cancer is the most prevalent condition among women, and biomarkers are crucial for disease diagnosis. HER2 is a significant protein marker in breast cancer biomarkers; however, it is also present in healthy individuals, making its quantification essential for disease detection. This paper presents a readily fabricated, rapid-response MoO₃_-CTAB based immunosensor for the sensitive and selective detection of HER2. The sensors efficiency during the preparation steps was assessed using differential pulse voltammetry (DPV) and cyclic voltammetry (CV) techniques. The DPV responses acquired from the designed sensor demonstrated a linear correlation with HER2 within the concentration range of 10 ng/mL to 125 ng/mL. The HER2 determination method yielded limit of detection (LOD) and limit of quantitation (LOQ) values of 2.85 ng/mL and 8.57 ng/mL, respectively. The immunosensor demonstrated significant selectivity against diverse interfering substances and effectively detected HER2 in commercial human serum samples, achieving recovery rates between 99.10% and 100.66%. Copyright

Breast cancer , Electrochemistry , HER2 , immunosensors , MoO₃-CTAB

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Department of Analytical, Colloidal Chemistry and Technology of Rare Elements, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara, 06560, Turkey
Ankara University, The Graduate School of Health Sciences, Ankara, 06110, Turkey

Department of Analytical
Ankara University
Ankara University

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