History of Endometriosis Is Independently Associated with an Increased Risk of Ovarian Cancer
Sarría-Santamera A. Khamitova Z. Gusmanov A. Terzic M. Polo-Santos M. Ortega M.A. Asúnsolo A.
August 2022MDPI
Journal of Personalized Medicine
2022#12Issue 8
Background: Endometriosis is a complex gynecologic disorder that has been associated with a higher risk of ovarian cancer. The purpose of this work is to determine to what extent a history of endometriosis is a risk factor for ovarian cancer in a Spanish population. Methods: A retrospective case–control study was conducted using de-identified data from the Spanish National Health System’s “Primary Care Clinical Database” and “Hospital Minimum Basic Data Set” for the period 2013–2017. Multiple logistics regression analysis was conducted to determine associations between ovarian cancer and endometriosis controlled by sociodemographic characteristics and comorbidities. Results: Data from 608,980 women were analyzed, with 4505 presenting ovarian cancer. Endometriosis patients were shown to have a 2.66-fold increased risk of ovarian cancer when compared to those who did not have endometriosis by controlling age and other relevant comorbidities. Conclusions: This case–control study based on clinical administrative data has found that a history of endometriosis is independently associated with an increased risk of ovarian cancer. More research is needed to determine if a history of endometriosis affects survival results in ovarian cancer patients.
endometriosis , ovarian cancer , risk , sociodemographic characteristics
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Department of Medicine, Nazarbayev University School of Medicine, Nur-Sultan, 020000, Kazakhstan
National Research Center for Maternal and Child Health, Clinical Academic Department of Women’s Health, University Medical Center, Nur-Sultan, 010000, Kazakhstan
Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, 15213, PA, United States
Agency for Health Technology Assessment, Institute of Health Carlos III, Madrid, 28029, Spain
Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, 28801, Spain
Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, 28034, Spain
Cancer Registry and Pathology Department, Hospital Universitario Principe de Asturias, Alcalá de Henares, 28805, Spain
Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcala, Alcalá de Henares, 28801, Spain
Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, The City University of New York, New York, 10017, NY, United States
Department of Medicine
National Research Center for Maternal and Child Health
Department of Obstetrics
Agency for Health Technology Assessment
Department of Medicine and Medical Specialities
Ramón y Cajal Institute of Sanitary Research (IRYCIS)
Cancer Registry and Pathology Department
Department of Surgery
Department of Epidemiology and Biostatistics
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