Association of CYP24A1 Gene rs6127099 (A > T) Polymorphism with Lower Risk to COVID-19 Infection in Kazakhstan

Sarría-Santamera A. Mukhtarova K. Baizhaxynova A. Kanatova K. Zhumambayeva S. Akilzhanova A. Azizan A.
February 2023 MDPI

Genes
2023 #14 Issue 2

In December 2019, SARS-CoV-2 was identified in Wuhan, China. Infection by SARS-CoV-2 causes coronavirus disease 2019 (COVID-19), which is characterized by fever, cough, dyspnea, anosmia, and myalgia in many cases. There are discussions about the association of vitamin D levels with COVID-19 severity. However, views are conflicting. The aim of the study was to examine associations of vitamin D metabolism pathway gene polymorphisms with symptomless COVID-19 susceptibility in Kazakhstan. The case-control study examined the association between asymptomatic COVID-19 and vitamin D metabolism pathway gene polymorphisms in 185 participants, who previously reported not having COVID-19, were PCR negative at the moment of data collection, and were not vaccinated. A dominant mutation in rs6127099 (CYP24A1) was found to be protective of asymptomatic COVID-19. Additionally, the G allele of rs731236 TaqI (VDR), dominant mutation in rs10877012 (CYP27B1), recessive rs1544410 BsmI (VDR), and rs7041 (GC) are worth consideration since they were statistically significant in bivariate analysis, although their independent effect was not found in the adjusted multivariate logistic regression model.

COVID-19 , immune system , metabolism , SARS-CoV-2 , vitamin D

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School of Medicine, Nazarbayev University, Astana, 010000, Kazakhstan
Department of Propedeutics of Children Disease, Astana Medical University, Astana, 010000, Kazakhstan
National Laboratory Astana, Nazarbayev University, Astana, 010000, Kazakhstan
College of Osteopathic Medicine, Touro University Nevada, Henderson, 89014, NV, United States

School of Medicine
Department of Propedeutics of Children Disease
National Laboratory Astana
College of Osteopathic Medicine

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