Contrast-Induced Kidney Injury Prediction in STEMI Patients Post-Coronary Intervention

Saparov E.B. Saparova A.S. Mugazov M.M.
2025 National Scientific Medical Center

Journal of Clinical Medicine of Kazakhstan
2025 #22 Issue 3 79 - 83 pp.

Introduction: Contrast-induced acute kidney injury (CI-AKI) is a significant complication following percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI). This study aims to develop a predictive model for CI-AKI using clinical, laboratory, and procedural data. Methods: A retrospective cohort study analyzed 78 STEMI patients undergoing PCI between November 2024 and April 2025. Data included demographics, clinical parameters, pre-and post-intervention laboratory markers (creatinine, GFR), hydration protocols, nephrotoxic medication use, and contrast type. CI-AKI was defined as a ≥25% increase in serum creatinine within 48 hours post-PCI. Logistic regression and R software (version 4.3.1) were used for statistical analysis and modeling, with performance assessed via AUC-ROC. Results: CI-AKI occurred in 19.2% of patients (15/78). Key predictors were age (OR 1.07, p=0.02), baseline creatinine (OR 1.85, p=0.01), and contrast dose (OR 1.01, p=0.03). The model achieved an AUC-ROC of 0.83 (95% CI: 0.72-0.94). CI-AKI patients had higher baseline creatinine (105.3 vs. 86.2 µmol/L, p=0.01) and older age (69.1 vs. 62.7 years, p=0.03). Conclusion: The model effectively predicts CI-AKI risk in STEMI patients post-PCI, with age, creatinine, and contrast dose as critical factors. Prospective multicenter validation is needed.

Contrast-induced kidney injury , creatinine , GFR , percutaneous coronary intervention , predictive modeling , STEMI

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Department emergency medicine, anesthesiology and resuscitation, NAO Karaganda Medical University, Karaganda, Kazakhstan
Trainer of the Center of Practical Skills, NAO Karaganda Medical University, Karaganda, Kazakhstan
Department of Emergency Medicine, Anesthesiology and Resuscitation NAO Karaganda Medical University, Karaganda, Kazakhstan

Department emergency medicine
Trainer of the Center of Practical Skills
Department of Emergency Medicine

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