Desensitization in kidney transplantation: Review
Saparbay J. Assykbayev M. Abdugafarov S. Zhakhina G. Spatayev J. Zhexembayev A. Zhanzakova Z. Turganbekova A. Abdrakhmanova S. Kulkayeva G.
2021National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2021#18Issue 632 - 34 pp.
Sensitization to human leukocyte antigens (HLA) antigens is the main obstacle to getting the kidney either from a living or deceased donor. HLA sensitization occurs as the result of repeated pregnancy, blood transfusion, or previous transplantation. Overcoming the HLA incompatibility is one of the approaches to decrease the organ shortage. There are 3.5% highly sensitized patients among 3012 patients on the waiting list for kidney transplantation in Kazakhstan. In this review, we have discussed most common approaches of desensitization for HS kidney recipients. Huge progress has been made in the field of desensitization in transplant medicine worldwide. We suppose, that implementation the desensitization protocols in clinical guidelines will improve patient survival and outcome after kidney transplantation.
HLA sensitization , immunology , kidney transplantation
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Department of Organ Transplantation, National Research Oncology Center, Nur-Sultan, Kazakhstan
Department of Immunological Support of Organ Transplantation, Research and Production Center for Transfusiology, Nur-Sultan, Kazakhstan
Department of Organ Transplantation
Department of Immunological Support of Organ Transplantation
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