Floral extracts-mediated green synthesis of NiO nanoparticles and their diverse pharmacological evaluations

Sani A. Hassan D. Khalil A.T. Mughal A. El-Mallul A. Ayaz M. Yessimbekov Z. Shinwari Z.K. Maaza M.
2021 Taylor and Francis Ltd.

Journal of Biomolecular Structure and Dynamics
2021 #39 Issue 11 4133 - 4147 pp.

Biosynthesis has emerged as an exciting interface for assembling multifunctional metal oxide nanoparticles for diverse medicinal applications. Herein, biogenic nickel oxide (NiO-NPs) is synthesized by using floral extracts of Callistemon viminalis (C. viminalis) as a low cost, ecofriendly reducing and stabilizing agent. NiO-NPs were annealed at 300 °C, 400 °C and 500 °C while their physiochemical properties were established by HR-SEM/TEM, UV, XRD, FTIR, EDS, SAED and SQUID techniques. Particle size of NiO-NPs decreased with increase in annealing temperatures. Magnetization curves indicated superparamagnetic behavior of the biogenic NiO-NPs at 300 K. Highly crystalline NiO-NPs obtained after annealing at 500 °C were used for biomedical applications. The anti-leishmanial activity on Leishmania tropica promastigotes (KMH-23) and anticancer activity on HepG2 (RCB1648) revealed excellent inhibition potential with IC₅₀ of 37.21 µg/mL and 47 µg/mL, respectively. Significant antibacterial effect was observed against Klebsiella pneumonia and Proteus vulgaris with MIC’s of 12.5 µg/mL each. Acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and α-glucosidase inhibitory potential were comparable with positive control drugs. Moderate antioxidant activities were observed. NiO-NPs were observed to be hemolytic (30%) at higher dose (1000 µg/mL). Overall, NiO-NPs revealed a multifunctional nature that can be explored for diverse biomedical applications. Communicated by Ramaswamy H. Sarma.

anti-leishmanial , anticancer , antimicrobial , Biosynthesis , Callistemon viminalis , cholinesterase inhibition , hemolysis , NiO-NPs

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National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan
UNESCO-UNISA Africa chair in Nanoscience and Nanotechnology, College of Graduate Studies, University of South Africa, Pretoria, South Africa
Nanosciences African Network (NANOAFNET), Materials Research Department, iThemba LABS, Cape Town, South Africa
Department of Biotechnology, Qarshi University, Lahore, Pakistan
College of Pharmacy, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Pakistan
Department of Food Engineering, Warsaw Medical University, Warszawa, Poland
Department of Pharmacy, University of Malakand, Chakdara, Pakistan
Department of Food Engineering, Shakarim State University of Semey, Semey City, Kazakhstan
Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan

National Center of Excellence in Analytical Chemistry
UNESCO-UNISA Africa chair in Nanoscience and Nanotechnology
Nanosciences African Network (NANOAFNET)
Department of Biotechnology
College of Pharmacy
Department of Food Engineering
Department of Pharmacy
Department of Food Engineering
Department of Biotechnology

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