Prospects of cyanobacterial pigment production: Biotechnological potential and optimization strategies
Sandybayeva S.K. Kossalbayev B.D. Zayadan B.K. Sadvakasova A.K. Bolatkhan K. Zadneprovskaya E.V. Kakimov A.B. Alwasel S. Leong Y.K. Allakhverdiev S.I. Chang J.-S.
November 2022Elsevier B.V.
Biochemical Engineering Journal
2022#187
Increasing awareness of the harmful effects of synthetic colorants has led consumers to favor the use of natural alternatives such as plant or microbial pigments in food and cosmetics. Cyanobacteria are a rich source of many natural biopigments that are of high commercial value. In the market, bio-based pigments are usually sold as extracts to reduce purification costs. Various cell disruption methods are used for pigment extraction, such as sonication, homogenization, high pressure, supercritical CO2 extraction, enzymatic extraction, as well as other promising novel extraction methods that make the production of cyanobacterial pigments economically viable. In addition, a continuous cultivation system is considered the most suitable cultivation mode for large-scale biomass production. However, a major limitation in the large-scale production of cyanobacterial pigments is the installation and operation costs. Thus, basic and applied research is still needed to overcome such limitations and enable cyanobacteria to enter the global market. This review focuses on various cyanobacterial pigments, their applications, and current biotechnological approaches to increase the production of biopigments for their potential use in the pharmaceutical, food, and cosmetic industries. The current state of production technologies based on either open pond systems or closed photobioreactors was compared. The potential of scientific and technological advances to increase yield and reduce production costs of cyanobacteria biomass-based pigments was also discussed.
Bioactive compounds , Bioprocess optimization , Cyanobacteria , Extraction and purification , Pigments
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Faculty of Biology and Biotechnology, Al-Farabi Kazakh, National University, Al-Farabi Avenue 71, Almaty, 050038, Kazakhstan
Department of Chemical and Biochemical Engineering, Geology and Oil-Gas Business Institute Named after K. Turyssov, Satbayev University, Institute of Chemical and Biological Technologies, Almaty, 050043, Kazakhstan
Controlled Photobiosynthesis Laboratory, K.A. Timiryazev Institute of Plant Physiology, RAS, Botanicheskaya Street 35, Moscow, 127276, Russian Federation
College of Science, King Saud University, Riyadh, 12372, Saudi Arabia
Department of Chemical and Materials Engineering, Tunghai University, Taichung, 407, Taiwan
Institute of Basic Biological Problems, RAS, Moscow Region, Pushchino, 1442290, Russian Federation
Faculty of Engineering and Natural Sciences, Bahcesehir University, Istanbul, Turkey
Research Center for Smart Sustainable Circular Economy, Tunghai University, Taichung, 407, Taiwan
Department of Chemical Engineering, National Cheng Kung University, Tainan, 701, Taiwan
Department of Chemical Engineering and Materials Science, Yuan Ze University, Chung-Li, Taiwan
Faculty of Biology and Biotechnology
Department of Chemical and Biochemical Engineering
Controlled Photobiosynthesis Laboratory
College of Science
Department of Chemical and Materials Engineering
Institute of Basic Biological Problems
Faculty of Engineering and Natural Sciences
Research Center for Smart Sustainable Circular Economy
Department of Chemical Engineering
Department of Chemical Engineering and Materials Science
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