Effects of low lactose mares milk yogurt consumption on gut microbiota function
Samat K. Nurislam M. Zhanel P. Dmitriy B. Dinar T. Indira U. Zhanagul K. Akmaral Z. Zharkyn J. Saniya K. Tultabayeva T. Almagul K.
2022Functional Food Institute
Functional Foods in Health and Disease
2022#12Issue 8455 - 464 pp.
Background: This study shows that the intake of low-lactose yogurt with the addition of mares milk can affect the composition, biodiversity, and functional potential of the intestinal microflora. Purpose of the study: To study the effect of low-lactose drinking yogurt from a combination of mares and cows milk on the composition and functional repertoire of the fecal microbiota of rats. Methods: The study of the effect of low-lactose drinking yogurt from a combination of mares and cows milk on the intestinal microflora was carried out by dietary intervention for 4 weeks. Changes in the fecal microbiota were determined using V1-V3 sequencing of the hypervariable target region of the 16S rRNA gene. Functional prediction was carried out on the basis of the taxonomic structure of the amplicon sequence. Results: The results demonstrated a decrease in overall biodiversity both within the samples and between groups of animals. Discriminatory analysis revealed an increase in the relative content of Ruminococcaceae, Peptostreptococcaceae, indeterminate taxon at phylum level, Prevotellaceae and a decrease in Helicobacteraceae, Eubacterium coprostanoligenes group, Muribaculaceae, Lachnospiraceae, Lactobacillaceae. In addition, changes in the microbial structure also affected the predicted functional repertoire of the gut microbiota. Conclusion: These results demonstrate the consumption of low-lactose drinking yogurt from a combination of mares and cows milk, for a short time, can affect the composition and functional repertoire of the fecal microbiota.
functional repertoire , Gut microbiome , low-lactose yogurt , microbial diversity , rats
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National Laboratory Astana, Nazarbayev University, Nur-Sultan, Z05H0P9, Kazakhstan
Innovative Center ArtScience, Nur-Sultan, Z00T3X6, Kazakhstan
Department of General Pharmacology, Astana Medical University, Nur-Sultan, Z10H9A6, Kazakhstan
National Center for Biotechnology, Nur-Sultan, Z05K8D5, Kazakhstan
Kazakhstan society of researchers of human microbiome, Nur-Sultan, Z05H0P9, Kazakhstan
S. Seifullin Kazakh Agro Technical University, Nur-Sultan, Z11F9K5, Kazakhstan
National Laboratory Astana
Innovative Center ArtScience
Department of General Pharmacology
National Center for Biotechnology
Kazakhstan society of researchers of human microbiome
S. Seifullin Kazakh Agro Technical University
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