Characterization of Endothelial Progenitor Cell: Past, Present, and Future
Salybekov A.A. Kobayashi S. Asahara T.
July 2022MDPI
International Journal of Molecular Sciences
2022#23Issue 14
Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Despite these promising results, widespread clinical acceptance of EPCs for clinical therapies remains hampered by several challenges. The challenges and issues surrounding the use of EPCs and the current paradigm being developed to improve the harvest efficiency and functionality of EPCs for application in regenerative medicine are discussed. It has been observed that controversies have emerged regarding the isolation techniques and classification and origin of EPCs. This manuscript attempts to highlight the concept of EPCs in a sequential manner, from the initial discovery to the present (origin, sources of EPCs, isolation, and identification techniques). Human and murine EPC marker diversity is also discussed. Additionally, this manuscript is aimed at summarizing our current and future prospects regarding the crosstalk of EPCs with the biology of hematopoietic cells and culture techniques in the context of regeneration-associated cells (RACs).
endothelial colony-forming cells , endothelial progenitor cells , extracellular vesicles , hemogenic angioblasts , regeneration-associated cells , resident endothelial progenitor cells
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Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, 2478533, Japan
Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, Kamakura, 2478533, Japan
Qazaq Institute of Innovative Medicine, Nur-Sultan, 010000, Kazakhstan
Kidney Disease and Transplant Center
Shonan Research Institute of Innovative Medicine
Qazaq Institute of Innovative Medicine
10 лет помогаем публиковать статьи Международный издатель
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