Cell therapy in kidney diseases: advancing treatments for renal regeneration
Salybekov A.A. Kinzhebay A. Kobayashi S.
2024Frontiers Media SA
Frontiers in Cell and Developmental Biology
2024#12
Kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), pose a significant global health challenge, with high morbidity and mortality rates driven by rising prevalence of risk factors such as diabetes and hypertension. Current therapeutic strategies are often limited, prompting the exploration of advanced cell therapies as potential solutions. This review provides a comprehensive overview of the state of cell therapies in kidney disease, tracing the progression from preclinical studies to clinical applications. Recent studies highlited that cell-based interventions offer kidney-protective properties through mechanisms such as paracrine signaling, immune modulation, and direct tissue integration, demonstrating potential in both AKI and CKD settings. Despite promising results, challenges remain in optimizing cell therapy protocols, including cell sourcing, delivery methods, and long-term outcomes. Finally, the review addresses on efforts to enhance cell function, optimize dosing, and refine delivery techniques to improve clinical outcomes in kidney disease management. Copyright
acute kidney injury , CD34 cells , cell therapy , chronic kidney diseases , kidney diseases , mesenchimal stem cells
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Qazaq Institute of Innovative Medicine, Regenerative Medicine Division, Cell and Gene Therapy Department, Astana, Kazakhstan
Kidney Diseases and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan
Qazaq Institute of Innovative Medicine
Kidney Diseases and Transplant Center
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026