Assessment of prognostic factors in extracranial germ cell tumors in children

Оценка факторов прогноза при экстракраниальных герминогенноклеточных опухолях у детей
Saliyeva S.S. Boranbayeva R.Z. Zhumadullayev B.M. Sarsekbayev E.S. Bydanov O.I.
2021 Autonomous non-profit scientific and medical organization

Voprosy Onkologii
2021 #67 Issue 6 829 - 836 pp.

Germ cell neoplasms in the group of benign and malignant tumors heterogeneous in morphological structure, clinical features and prognosis. A special characteristic of germ cell tumors is their high sensitivity to platinum-containing chemotherapy, which allows cure of up to 80-90% patients. However 20-25% of patients with a common type have overall survival rate of less than 50%. The aim of the study is to assess the survival rate of children with extracranial germ cell tumors and to identify adverse risk factors. Methods. The study includes 116 children with extracranial germ cell tumors treated from 2013 to September 2009. Treatment consisted of tumor resection and platinum based on platinum chemotherapy. Survival rate was assessed by the Kaplan-Mayer method. Prognostic factors are determined according to IGCCCG, MaGIC, MAKEI, RODO. Results. Overall and event free survival rates were 79±5% and 76±4%, respectively. The worst overall survival had patients with extragonadal tumors, advanced stages of a disease, high initial level of AFP (>10 000 ng/ml), non-seminoma version of state treasury bills and extra pulmonary metastases. Conclusion. Survival rate in children with extracranial germ cell tumors depends on the prognostic factors. Statistically significant predictors of the poor prognosis were extragonadal localization of a tumor and the AFP level >10 000 ng/ml.

child , germ cell tumors , prognosis , survival

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Scientific Center of Pediatrics and Child Surgery of the Ministry of Health of the Republic of Kazakhstan JMC, Almaty, Kazakhstan
Republikan Scientific and Practical Center for Pediatric Oncology, Hematology and Immunology of the Ministry of Health of the Republic of Belarus, Minsk, Belarus

Scientific Center of Pediatrics and Child Surgery of the Ministry of Health of the Republic of Kazakhstan JMC
Republikan Scientific and Practical Center for Pediatric Oncology

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