Role of ethnic and genetic factors in the development of prostate cancer (Review)
Saliev T. Akhmad N. Altynbekova S. Nogaeva M. Tazhieva A. Dushimova Z.
January 2025Spandidos Publications
World Academy of Sciences Journal
2025#7Issue 1
Prostate cancer (PCa) is one of the most common malignancies worldwide, particularly affecting older males. Genetic and ethnic factors play a critical role in the develop‑ ment, progression and mortality rate associated with PCa. The present review focuses on the influence of race and genetic predisposition, particularly the mutations in BRCA1 and BRCA2 genes, which markedly increase the risk of devel‑ oping aggressive forms of PCa. African American males, in particular, are more susceptible to PCa, with a higher inci‑ dence of aggressive disease compared to other ethnic groups. These genetic disparities highlight the importance of targeted genetic screening and personalized healthcare strategies to mitigate the risk of developing PCa in vulnerable popula‑ tions. The key conclusions from the present review emphasize the necessity of integrating genetic testing into routine PCa screening protocols, particularly for high‑risk groups, such as males with a family history of PCa or those of African descent. Personalized treatment options, such as the use of PARP inhibitors for patients with BRCA mutations, present a promising approach to improving the outcomes of patients with PCa. The present review calls for further research into the interactions between genetic and environmental factors in PCa and the development of tailored intervention programs to reduce incidence and mortality among high‑risk populations. Expanding access to genetic counselling and testing services is crucial to improving early detection and preventive care. Copyright
BRCA1 , BRCA2 , prostate cancer , race , risk factors
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Institute for Fundamental and Applied Medical Research, S.D. Asfendiyarov Kazakh National Medical University, Almaty, 050000, Kazakhstan
Department of Normal Anatomy, S.D. Asfendiyarov Kazakh National Medical University, Almaty, 050000, Kazakhstan
Department of Endocrinology, S.D. Asfendiyarov Kazakh National Medical University, Almaty, 050000, Kazakhstan
Department of Rheumatology, S.D. Asfendiyarov Kazakh National Medical University, Almaty, 050000, Kazakhstan
Department of Science, S.D. Asfendiyarov Kazakh National Medical University, Almaty, 050000, Kazakhstan
Department of Fundamental Medicine, Al‑Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Institute for Fundamental and Applied Medical Research
Department of Normal Anatomy
Department of Endocrinology
Department of Rheumatology
Department of Science
Department of Fundamental Medicine
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