Epidemiology of spontaneous pregnancy loss in Kazakhstan: A national population-based cohort analysis during 2014–2019 using the national electronic healthcare system
Sakko Y. Turesheva A. Gaipov A. Aimagambetova G. Ukybassova T. Marat A. Kaldygulova L. Amanzholkyzy A. Nogay A. Khamidullina Z. Mussenov Y. Almawi W.Y. Atageldiyeva K.
December 2023John Wiley and Sons Inc
Acta Obstetricia et Gynecologica Scandinavica
2023#102Issue 121682 - 1693 pp.
Introduction: Spontaneous pregnancy loss (SPL) is a common health problem that affects 1:10 of childbearing women, and is linked with physical and psychological complications. As the number of nationwide studies on the incidence of SPL is few, especially from middle-income countries, in this study we investigated the epidemiology, complications and outcomes of SPL before 22 weeks of gestation by analyzing large-scale healthcare data from the Unified Nationwide Electronic Healthcare System (UNEHS) in Kazakhstan. Material and methods: A population-based study among women who experienced SPL in any healthcare setting of the Republic of Kazakhstan during the period of 2014–2019. The International Classification of Diseases (ICD) 10th edition and ICD 9th editions procedural codes were utilized to retrieve data using relevant diagnostic and procedural codes. Results: In total, 207 317 records of women who have experienced an SPL before 22 weeks of gestation were analyzed from all Kazakhstani regions. The estimated prevalence of SPL was 8.7%, with a 20% decline over a 6-year period. The SPL cases ratio comprises on average 6.2 per 1000 reproductive-age women. Incomplete miscarriage (ICD-10 code “O03.4”) was the most common type (37.8%), followed by blighted ovum (ICD-10 code “O02.0”; 34.1%) and missed abortion (ICD-10 code “O02.1”; 13.5%). The most common management methods were dilation and curettage of the uterus (ICD-9 code “69.0”; 84.7%) and aspiration curettage of the uterus (ICD-9 code “65.0”; 15%), whereas medical management was rarely performed (2.6%). Conclusion: The information available in UNEHS adequately identifies types of miscarriages and treatment methods. Although the prevalence of SPL before 22 weeks of gestation is decreasing, management of miscarriages requires closer attention.
epidemiology , maternity care , miscarriage , spontaneous pregnancy loss , womens health issues
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Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Department of Normal Physiology, West-Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Surgery, School of Medicine, Nazarbayev University, Astana, Kazakhstan
Clinical Academic Department of Womens Health, CF “University Medical Center”, Astana, Kazakhstan
Department of Obstetrics and Gynecology #1, NJSC “Astana Medical University”, Astana, Kazakhstan
Department of Obstetrics and Gynecology #2, West-Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Astana City Polyclinic #12, Astana, Kazakhstan
Science Faculty of Tunisia, Université de Tunis El Manar, Tunis, Tunisia
Department of Medicine
Department of Normal Physiology
Department of Surgery
Clinical Academic Department of Womens Health
Department of Obstetrics and Gynecology #1
Department of Obstetrics and Gynecology #2
Astana City Polyclinic #12
Science Faculty of Tunisia
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