Impact of antenatal and intrapartum risk factors on the development of bronchopulmonary dysplasia in preterm infants

Sairankyzy S. Seisebayeva R.Zh. Sagatbayeva N.A. Abdullayeva G.M. Bozhbanbayeva N.S. Nurgaliyeva Z.Zh. An O.O. Sadykova A.Zh. Ablaikhanova N.T. Umbetyarova L.B.
2025 Dynasty Publishing House

Voprosy Ginekologii, Akusherstva i Perinatologii
2025 #24 Issue 3 27 - 34 pp.

Objective. To study antenatal and intrapartum risk factors in mothers of preterm infants with bronchopulmonary dysplasia (BPD). Patients and methods. A retrospective case-control study was conducted. Medical records of 111 mothers of preterm infants with BPD (study group) and 109 mothers of preterm infants without BPD (comparison group) for the period 2013–2017 were analyzed. Multiple logistic regression was used to identify antenatal and intrapartum risk factors associated with the development of BPD in preterm infants. Results. Multiple logistic regression showed a positive association of maternal arterial hypertension (Exp(B) = 0.424, 95% CI 0.183–0.970, p = 0.042), maternal edema (Exp(B) = 6.088, 95% CI 1.557–23.802, p = 0.009), polyhydramnios (Exp(B) = 9.925, 95% CI 1.176–83.742, p = 0.035), administration of antenatal steroids for preventing respiratory distress syndrome (RDS) (Exp(B) = 3.161, 95% CI 1.678–5.952, p < 0.001) with BPD in preterm infants. Conclusion. Arterial hypertension, edema during pregnancy, polyhydramnios, and administration of antenatal steroids for RDS significantly increase the risk of BPD in preterm infants.

antenatal period , bronchopulmonary dysplasia , intrapartum period , prematurity , preterm labor , risk factors

Text of the article Перейти на текст статьи

Department of Neonatology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Propaedeutics of Childhood Diseases, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Ambulatory-Polyclinic Pediatrics, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
N.A.Barlybaeva Department of Childhood Diseases, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Biophysics and Biomedicine, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Al-Farabi Kazakh National University, Almaty, Kazakhstan

Department of Neonatology
Asfendiyarov Kazakh National Medical University
Department of Propaedeutics of Childhood Diseases
Department of Ambulatory-Polyclinic Pediatrics
N.A.Barlybaeva Department of Childhood Diseases
Department of Biophysics and Biomedicine
Al-Farabi Kazakh National University

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026