The histological assessment of new bone formation with zolendronic acid loaded bone allograft in rabbit femoral bone defect
Saginova D. Tashmetov E. Kamyshanskiy Y. Koshanova A. Arutyunyan M. Rustambek I.
2023Carol Davila University Press
Journal of Medicine and Life
2023#16Issue 4616 - 622 pp.
The aim of this experimental study was to evaluate the effect of zolendronic acid (ZOL) combined with bone al-lograft prepared using the Marburg Bone Bank System on bone formation in the implant remodeling zone. Femoral bone defects with a diameter of 5 mm and a depth of 10 mm were created in 32 rabbits. Animals were divided into 2 similar groups: Group 1 (control), where defects were filled with bone allograft, and Group 2, where allograft was combined with ZOL. Eight animals from each group were sacrificed at 14-and 60-days post-surgery and bone de-fect healing was assessed using histopathological and histomorphometric analyses after 14 and 60 days. The results showed that new bone formation within the bone allograft was significantly greater in the control group than in the ZOL-treated group after 14 and 60 days (p<0.05). In conclusion, local co-administration of ZOL on heat-treated allograft inhibits allograft resorption and new bone formation in the bone defect.
bone allograft , bone regeneration , Marburg bone bank system , zolendronic acid
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Center for Applied Scientific Research, National Scientific Center of Traumatology and Orthopaedics named after academician N.D.Batpenov, Nur-Sultan, Kazakhstan
Department of Surgical Diseases, Karaganda Medical University, Karaganda, Kazakhstan
Institute of Pathology of the University Clinic, Karaganda Medical University, Karaganda, Kazakhstan
Center for Applied Scientific Research
Department of Surgical Diseases
Institute of Pathology of the University Clinic
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