Effect of autologous platelet-rich plasma on new bone formation and viability of a Marburg bone graft

Saginova D. Tashmetov E. Tuleubaev B. Kamyshanskiy Y.
1 January 2023 Walter de Gruyter GmbH

Open Life Sciences
2023 #18 Issue 1

This study aimed to compare the new bone formation, the process of remodeling, and the viability of bone grafts, using a combination of platelet-rich plasma (PRP) and Marburg bone graft versus bone grafts without any additional elements. For this study, 48 rabbits (with 24 rabbits in each group) were used. Bone defects were made in the femur, and the bone graft used was the human femoral head prepared according to the Marburg Bone Bank. Rabbits were divided into the following groups: heat-Treated bone graft (HTBG group) and HTBG with PRP (HTBG + PRP group). After 14, 30, and 60 days post-surgery, the assessment of the results involved X-ray, histopathological, and histomorphometric analyses. The greater new bone formation was detected in the HTBG + PRP group on the 14 and 30 day (p < 0.001). Furthermore, the group using bone grafts with PRP demonstrated notably enhanced remodeling, characterized by stronger bone integration, more significant graft remineralization, and a circular pattern of newly formed bone. The PRP-bone graft complex improves bone tissue repair in the bone defect in the initial stages of bone regeneration. PRP has been identified to enhance the remodeling process and amplify the osteoconductive and osteoinductive capabilities of HTBGs.

bone defect , bone graft , Marburg bone bank system , PRP

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The Center for Applied Scientific Research, National Scientific Center of Traumatology and Orthopaedics Named after Academician, N.D. Batpenov, Astana, 010000, Kazakhstan
Department of Surgical Diseases, Karaganda Medical University, Karaganda, 100000, Kazakhstan
Pathology Unit of the University Clinic, Karaganda Medical University, Karaganda, 100000, Kazakhstan

The Center for Applied Scientific Research
Department of Surgical Diseases
Pathology Unit of the University Clinic

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