Synthesis of New Hydrazones Based on 1-(1-Tosylpyrrolidin-2-yl)propan-2-one
Sadykova Y.M. Smolobochkin A.V. Turmanov R.A. Zalaltdinova A.V. Gazizov A.S. Pudovik M.A. Burilov A.R.
July 2024Pleiades Publishing
Russian Journal of General Chemistry
2024#94Issue 71625 - 1629 pp.
Abstract: A method was developed for synthesizing previously unknown hydrazones containing two pharmacophoric fragments in their structure based on the reaction of phenyl/acylhydrazines with 1-(1-tosylpyrrolidin-2-yl)propan-2-one. Structure of the resulting hydrazones was established using 1H, 13C NMR, IR spectroscopy, and mass spectrometry (ESI-TOF) data. Based on 1D/2D correlation NMR experiments, it was found that the resulting hydrazones exist only as E-isomer.
1-(1-tosylpyrrolidin-2-yl)propan-2-one , Girard P reagent , Girard T reagent , hydrazones , isonicotine hydrazide , nicotine hydrazide
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Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”, Kazan, 420088, Russian Federation
Laboratory of Engineering Profile “Physical and Chemical Methods of Analysis”, Korkyt Ata Kyzylorda University, Kyzylorda, 120014, Kazakhstan
Arbuzov Institute of Organic and Physical Chemistry
Laboratory of Engineering Profile “Physical and Chemical Methods of Analysis”
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