Biomarker urinary neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury in neonates
Sadykova A. Boranbayeva R. Tashenova G. Berdiyarova G. Tulebayeva A. Zhovnir V. Fakhradiyev I.
2025Taylor and Francis Ltd.
Future Science OA
2025#11Issue 1
Aim: To evaluate urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as a predictive biomarker for Acute Kidney Injury (AKI) in neonates undergoing gastrointestinal surgery. Materials & Methods: A prospective cohort study included 45 neonates with gastrointestinal congenital malformations who underwent abdominal surgery within the first 28 days of life at two pediatric centers in Almaty, Kazakhstan. AKI was diagnosed using modified neonatal KDIGO criteria, dividing neonates into AKI[+] and AKI[-] groups. uNGAL levels were measured pre-surgery and on postoperative days 1, 3, and 7. Statistical analysis, including ROC curve analysis, was performed using SPSS to evaluate uNGAL’s sensitivity and specificity as a biomarker. Results: AKI was diagnosed in 42.2% of neonates. Pre-surgery uNGAL levels were significantly higher in the AKI group (184.4 ng/ml vs. 56.5 ng/ml). Post-surgery, uNGAL peaked at 493.9 ng/ml on day 1, with sensitivities of 89.5% and 94.7% on days 1 and 7. Specificity was highest on days 1 and 3 (96.2% and 100%). The mortality rate among AKI-affected neonates was 31.5%. Conclusion: uNGAL is a sensitive and specific biomarker for early AKI detection in neonates post-gastrointestinal surgery, enabling timely interventions and potentially reducing mortality.
abdominal surgery , acute kidney injury , General surgery , Neonatal AKI , neonate , perioperative AKI , postoperative
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Department of Medicine, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Medicine, National specialized children’s hospital “Ohmatdyt” Ministry of Health of Ukraine, Kyiv, Ukraine
College of Medicine, Korea University, Seoul, South Korea
Department of Medicine
Department of Medicine
College of Medicine
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026