Rotational Barriers in N-Benzhydrylformamides: An NMR and DFT Study
Sadvakassova M.Z. Khlebnikov A.I. Bakibaev A.A. Kotelnikov O.A. Erkassov R.S. Yelubay M.A. Issabayeva M.A.
January 2023MDPI
Molecules
2023#28Issue 2
N-Benzhydrylformamides are pharmacologically active compounds with anticonvulsant, enzyme-inducing, antihypoxic, and other types of biological activity. The conformational behavior of benzhydrylformamides is determined to a great extent by the presence of substituents at the nitrogen atom and in the ortho-position(s) of the diphenylmethane moiety. Particularly, the NMR spectra of these compounds often contain two sets of signals originating from different orientations of the formyl group. With the use of the dynamic NMR method and DFT calculations, we investigated the internal rotations of aromatic and formyl fragments and estimated the corresponding rotational barriers in N-benzhydrylformamide (BHFA), N-methyl-N-benzhydrylformamide (BHFA-NMe), and in a series of ortho-halogen-substituted N-benzhydrylformamides. It was found that the DFT method at M06-2X/6-311+G* level of theory satisfactorily reproduces the experimental barrier (Formula presented.) (Formyl) of the formyl group rotation in BHFA-NMe. In BHFA, BHFA-NMe, and in the ortho-halogen derivatives, the calculated (Formula presented.) (Formyl) values are close to each other and lie within 20–23 kcal/mol. On the other hand, the ortho-substituents significantly hinder the rotation of aryl fragment with (Formula presented.) (Aryl) values varying from 2.5 kcal/mol in BHFA to 9.8 kcal/mol in ortho-iodo-N-benzhydrylformamide.
DFT calculations , dynamic NMR , N-benzhydrylformamide derivatives , rotational barriers
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Department of Chemistry, L.N. Gumilyov Eurasian National University, Astana, 010008, Kazakhstan
Kizhner Research Center, Tomsk Polytechnic University, Tomsk, 634050, Russian Federation
Faculty of Chemistry, National Research Tomsk State University, Tomsk, 634050, Russian Federation
Department of Chemistry and Chemical Technology, Toraighyrov University, Pavlodar, 140008, Kazakhstan
Department of Chemistry
Kizhner Research Center
Faculty of Chemistry
Department of Chemistry and Chemical Technology
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